Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcoma

Fujimoto, Akihito; Sasaki, Jin-ichi; Hosokawa, Masashi et al.

Fisheries Science, 2002, 68(Supplement 2), 1639-1640

Permalink : https://hdl.handle.net/2115/49564

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アクセス権
open access
URI
https://hdl.handle.net/2115/49564
タイトル
Liposomal sn-2 DHA inserted phospholipid decreases tumor size of fibrosarcoma
著者
Fujimoto, Akihito ; Sasaki, Jin-ichi ; Hosokawa, Masashi ; Takahashi, Koretaro
著者名
Fujimoto, Akihito
著者名
Sasaki, Jin-ichi
e-Rad_Researcher
10241374
著者名
Hosokawa, Masashi
e-Rad_Researcher
90125328
著者名
Takahashi, Koretaro
言語
英語
キーワード
phospholipid
liposome
fibrosarcoma
phagocytosis
antitumor
発行日
2002
出版者
Japanese Society of Fisheries Science
収録物名
Fisheries Science
巻(号)
68(Supplement 2)
ページ
1639-1640
抄録
Liposomes especially the multilamella vesicles (MLV) are known to be phagocyted by macrophages. This was considered to be a problem when designing a drug delivery system. If we take another way of looking at this problem, we could take advantage of this draw back of MLV. For instance, by encapsulating a biological response modifier, we may activate macrophages. The sn-2 docosahexaenoic acid (DHA) inserted phospholipids (2-DHA-PL) have been receiving attentions on their boosting effects on functional compounds such as retinoid or hormones without any serious side effect. For this reason, it is expected to enhance therapeutic effects of the encapsulated compound. In this study, we evaluated the antitumor activity of 2-DHA-PL liposome against Meth-A fibrosarcoma both in vitro and in vivo.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
© 2002 公益社団法人日本水産学会
© 2002 The Japanese Society of Fisheries Science
PISSN
0919-9268
NCID
AA10993718
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.2331/fishsci.68.sup2_1639