Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation

Kondo, Takeshi; Yasumoto, Atsushi; Arita, Kotaro; Sugita, Jun-ichi; Shigematsu, Akio; Okada, Kohei; Takahata, Mutsumi; Onozawa, Masahiro; Kahata, Kaoru; Takeda, Yukari; Obara, Masato; Yamamoto, Satoshi; Endo, Tomoyuki; Nishio, Mitsufumi; Sato, Norihiro; Tanaka, Junji; Hashino, Satoshi; Koike, Takao; Asaka, Masahiro; Imamura, Masahiro

Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation

Kondo, Takeshi; Yasumoto, Atsushi; Arita, Kotaro et al.

International Journal of Hematology, 2010, 91(2), 310-321

Permalink : https://hdl.handle.net/2115/49669

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アクセス権	open access
URI	https://hdl.handle.net/2115/49669
タイトル	Successful treatment of acute myelogenous leukemia with favorable cytogenetics by reduced-intensity stem cell transplantation
著者	Kondo, Takeshi ; Yasumoto, Atsushi ; Arita, Kotaro ; Sugita, Jun-ichi ; Shigematsu, Akio ; Okada, Kohei ; Takahata, Mutsumi ; Onozawa, Masahiro ; Kahata, Kaoru ; Takeda, Yukari ; Obara, Masato ; Yamamoto, Satoshi ; Endo, Tomoyuki ; Nishio, Mitsufumi ; Sato, Norihiro ; Tanaka, Junji ; Hashino, Satoshi ; Koike, Takao ; Asaka, Masahiro ; Imamura, Masahiro
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Yasumoto, Atsushi
著者名 Arita, Kotaro
著者名 Sugita, Jun-ichi
著者名 Shigematsu, Akio
著者名 Okada, Kohei
著者名 Takahata, Mutsumi
e-Rad_Researcher 70455632 著者名 Onozawa, Masahiro
著者名 Kahata, Kaoru
著者名 Takeda, Yukari
著者名 Obara, Masato
著者名 Yamamoto, Satoshi
著者名 Endo, Tomoyuki
e-Rad_Researcher 10322801 著者名 Nishio, Mitsufumi
著者名 Sato, Norihiro
e-Rad_Researcher 50250452 著者名 Tanaka, Junji
e-Rad_Researcher 60271665 著者名 Hashino, Satoshi
e-Rad_Researcher 80146795 著者名 Koike, Takao
e-Rad_Researcher 10113507 著者名 Asaka, Masahiro
e-Rad_Researcher 20160062 著者名 Imamura, Masahiro
言語	英語
キーワード	AML
	Favorable karyotype
	RIST
発行日	2010-03
出版者	Springer Japan
収録物名	International Journal of Hematology
巻(号)	91(2)
ページ	310-321
抄録	Acute myelogenous leukemia (AML) with favorable cytogenetics responds well to chemotherapy. If the leukemia relapses, allogenic hematopoietic stem transplantation (allo-HSCT) is considered as a treatment option. Since the efficacy of reduced-intensity stem cell transplantation (RIST) for AML with favorable cytogenetics has not been established, we retrospectively analyzed the outcomes of allo-HSCT in AML patients according to cytogenetic risks. The outcome of allo-HSCT for AML patients with favorable cytogenetics seemed to be superior to that for AML patients with intermediate cytogenetics. In AML patients with favorable cytogenetics, the 3-year overall survival (OS) and relapse-free survival (RFS) rates were 88% and 76%, respectively, in the RIST group. Both the 3-year OS and RFS rates were 81% in the conventional stem cell transplantation (CST) group. The outcome of RIST for AML patients with favorable cytogenetics was comparable to that for patients who received CST despite the more advanced age and greater organ dysfunction in RIST group than in CST group. None of the patients died within 90 days after RIST. Moreover, there was no relapse in patients with favorable cytogenetics who were in hematological remission prior to RIST. Thus, RIST for AML patients with favorable cytogenetics in remission is safe and effective.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at www.springerlink.com
PISSN	0925-5710
EISSN	1865-3774
関連情報	PMID 20087795
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s12185-009-0487-y