Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice

Danzaki, Keiko; Matsui, Yutaka; Ikesue, Masahiro; Ohta, Daichi; Ito, Koyu; Kanayama, Masashi; Kurotaki, Daisuke; Morimoto, Junko; Iwakura, Yoichiro; Yagita, Hideo; Tsutsui, Hiroyuki; Uede, Toshimitsu

Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice

Danzaki, Keiko; Matsui, Yutaka; Ikesue, Masahiro et al.

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32(2), 273-280

Permalink : https://hdl.handle.net/2115/49684

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/49684
タイトル	Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient Mice
著者	Danzaki, Keiko ; Matsui, Yutaka ; Ikesue, Masahiro ; Ohta, Daichi ; Ito, Koyu ; Kanayama, Masashi ; Kurotaki, Daisuke ; Morimoto, Junko ; Iwakura, Yoichiro ; Yagita, Hideo ; Tsutsui, Hiroyuki ; Uede, Toshimitsu
著者名 Danzaki, Keiko
e-Rad_Researcher 30431381 著者名 Matsui, Yutaka
著者名 Ikesue, Masahiro
著者名 Ohta, Daichi
著者名 Ito, Koyu
著者名 Kanayama, Masashi
著者名 Kurotaki, Daisuke
e-Rad_Researcher 20451396 著者名 Morimoto, Junko
著者名 Iwakura, Yoichiro
著者名 Yagita, Hideo
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
e-Rad_Researcher 00160185 著者名 Uede, Toshimitsu
言語	英語
キーワード	atherosclerosis
	CD4 positive T cells
	high fat diet
	interferon gamma
	interleukin-17A
	IL-17A
	IFN-γ
発行日	2012-02
出版者	American Heart Association
収録物名	Arteriosclerosis, Thrombosis, and Vascular Biology
巻(号)	32(2)
ページ	273-280
抄録	Objective: Interleukin-17A (IL-17A), an inflammatory cytokine, has been implicated in atherosclerosis, in which inflammatory cells within atherosclerotic plaques express IL-17A. However, its role in the development of atheroscelrosis remains to be controversial. Methods and Results: To directly examine the role of IL-17A in atherosclerosis, we generated apolipoprotein E (ApoE)/IL-17A double-deficient (ApoE^[-/-]IL-17A^[-/-]) mice. Mice were fed with high-fat diet (HFD) for either 8 or 16 weeks, both starting at ages of 6-8 weeks. We found that splenic CD4+ T cells produced high amounts of IL-17A in ApoE^[-/-] mice after HFD feeding for 8 weeks. Atherosclerosis was significantly accelerated in HFD-fed ApoE^[-/-]IL-17A^[-/-] mice compared with ApoE^[-/-] mice. Splenic CD4+ T-cells of ApoE^[-/-]IL-17A^[-/-] mice after HFD feeding for 8 weeks, but not for 16 weeks, exhibited increased IFN-γ and decreased IL-5 production. Importantly, formation of vulnerable plaque as evidenced by reduced numbers of vascular smooth muscle cells and reduced type I collagen deposition in the plaque was detected in ApoE^[-/-]IL-17A^[-/-] mice after HFD feeding for 8 weeks. Conclusions: These results suggest that IL-17A regulates the early phase of atherosclerosis development after HFD feeding and plaque stability, at least partly if not all by modulating IFN-γ and IL-5 production from CD4+ T-cells.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1079-5642
関連情報	PMID 22116098
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1161/ATVBAHA.111.229997