Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD

Sugita, Junichi; Matsushita, Takae; Kashiwazaki, Haruhiko; Kosugi, Mizuha; Takahashi, Shojiro; Wakasa, Kentaro; Shiratori, Souichi; Ibata, Makoto; Shono, Yusuke; Shigematsu, Akio; Obara, Masato; Fujimoto, Katsuya; Endo, Tomoyuki; Nishio, Mitsufumi; Kondo, Takeshi; Hashino, Satoshi; Tanaka, Junji; Asaka, Masahiro; Imamura, Masahiro

Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD

Sugita, Junichi; Matsushita, Takae; Kashiwazaki, Haruhiko et al.

Bone Marrow Transplantation, 2012, 47(2), 258-264

Permalink : https://hdl.handle.net/2115/49685

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アクセス権	open access
URI	https://hdl.handle.net/2115/49685
タイトル	Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD
著者	Sugita, Junichi ; Matsushita, Takae ; Kashiwazaki, Haruhiko ; Kosugi, Mizuha ; Takahashi, Shojiro ; Wakasa, Kentaro ; Shiratori, Souichi ; Ibata, Makoto ; Shono, Yusuke ; Shigematsu, Akio ; Obara, Masato ; Fujimoto, Katsuya ; Endo, Tomoyuki ; Nishio, Mitsufumi ; Kondo, Takeshi ; Hashino, Satoshi ; Tanaka, Junji ; Asaka, Masahiro ; Imamura, Masahiro
著者名 Sugita, Junichi
著者名 Matsushita, Takae
e-Rad_Researcher 10344516 著者名 Kashiwazaki, Haruhiko
著者名 Kosugi, Mizuha
著者名 Takahashi, Shojiro
著者名 Wakasa, Kentaro
著者名 Shiratori, Souichi
著者名 Ibata, Makoto
著者名 Shono, Yusuke
著者名 Shigematsu, Akio
著者名 Obara, Masato
著者名 Fujimoto, Katsuya
著者名 Endo, Tomoyuki
e-Rad_Researcher 10322801 著者名 Nishio, Mitsufumi
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
e-Rad_Researcher 60271665 著者名 Hashino, Satoshi
e-Rad_Researcher 50250452 著者名 Tanaka, Junji
e-Rad_Researcher 10113507 著者名 Asaka, Masahiro
e-Rad_Researcher 20160062 著者名 Imamura, Masahiro
言語	英語
キーワード	oral mucositis
	folinic acid
	stem cell transplantation
	SCT
発行日	2012-02
出版者	Nature Publishing Group
収録物名	Bone Marrow Transplantation
巻(号)	47(2)
ページ	258-264
抄録	Since the safety of folinic acid administration and its efficacy for reducing the toxicity of methotrexate (MTX) remain controversial, we assessed the effect of folinic acid administration after MTX treatment for GVHD prophylaxis on the incidence of oral mucositis and acute GVHD. We retrospectively analyzed data for 118 patients who had undergone allogeneic hematopoietic stem cell transplantation and had received MTX for GVHD prophylaxis. Multivariate analysis showed that systemic folinic acid administration significantly reduced the incidence of severe oral mucositis (OR = 0.13, 95%CI 0.04-0.73, P = 0.014). There was also a tendency for lower incidence of severe oral mucositis in patients who received folinic acid mouthwash (OR = 0.39, 95%CI 0.15-1.00, P = 0.051). No significant difference was observed in the incidence of acute GVHD between patients who received systemic folinic acid administration and those who did not (P = 0.88). Systemic folinic acid administration and mouthwash appear to be useful for reducing the incidence of severe oral mucositis in patients who have received allogeneic hematopoietic mucositis in patients who have received allogeneic hematopoietic stem cell transplantation using MTX as GVHD prophylaxis.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0268-3369
関連情報	PMID 21423118
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1038/bmt.2011.53