Aldehyde oxidase 1 gene is regulated by Nrf2 pathway

Maeda, Kenichiro; Ohno, Takashi; Igarashi, Shizuka et al.

Gene, 2012, 505(2), 374-378

Permalink : https://hdl.handle.net/2115/50082

このアイテムのアクセス数:1,715件（2026-02-07 03:57 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
Gen505-2_374-378 pdf 2.46 MB 1,762

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/50082
タイトル
Aldehyde oxidase 1 gene is regulated by Nrf2 pathway
著者
Maeda, Kenichiro ; Ohno, Takashi ; Igarashi, Shizuka ; Yoshimura, Takaaki ; Yamashiro, Koji ; Sakai, Masaharu
著者名
Maeda, Kenichiro
著者名
Ohno, Takashi
著者名
Igarashi, Shizuka
著者名
Yoshimura, Takaaki
著者名
Yamashiro, Koji
e-Rad_Researcher
50162269
著者名
Sakai, Masaharu
言語
英語
キーワード
Aldehyde oxidase 1
Nrf2-Small Maf heterodimer
Antioxidant responsive element (ARE)
Drug metabolism
発行日
2012-09-01
出版者
Elsevier B.V.
収録物名
Gene
巻(号)
505(2)
ページ
374-378
抄録
Aldehyde oxidase is a member of the molybd-flavo enzyme family that catalyzes the hydroxylation of heterocycles and the oxidation of aldehydes into corresponding carboxylic acids. Aldehyde oxidase-1 (AOX1) is highly expressed in liver and is involved in the oxidation of a variety of aldehydes and nitrogenous heterocyclic compounds, including anti-cancer and immunosuppressive drugs. However, the physiological substrates of AOX1 have not been identified, and it was unknown how the expression of AOX1 is regulated. Here, we found that the AOX1 gene is regulated by the Nrf2 pathway. Two Nrf2 binding consensus elements (anti-oxidant responsive element, ARE) are located in the 5' upstream region of the rat AOX1 gene. Molecular analyses using reporter transfection analysis, EMSA, and ChIP analysis show that Nrf2 binds to and strongly activates the rat AOX1 gene.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0378-1119
関連情報
PMID
22705828
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.gene.2012.06.010