Relationships between gill Na+,K+-ATPase activity and endocrine and local insulin-like growth factor-I levels during smoltification of masu salmon (Oncorhynchus masou)

Shimomura, Takahiro; Nakajima, Takuro; Horikoshi, Moeri; Iijima, Anai; Urabe, Hirokazu; Mizuno, Shinya; Hiramatsu, Naoshi; Hara, Akihiko; Shimizu, Munetaka

Relationships between gill Na+,K+-ATPase activity and endocrine and local insulin-like growth factor-I levels during smoltification of masu salmon (Oncorhynchus masou)

Shimomura, Takahiro; Nakajima, Takuro; Horikoshi, Moeri et al.

General and Comparative Endocrinology, 2012, 178(2), 427-435

Permalink : https://hdl.handle.net/2115/50106

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アクセス権	open access
URI	https://hdl.handle.net/2115/50106
タイトル	Relationships between gill Na+,K+-ATPase activity and endocrine and local insulin-like growth factor-I levels during smoltification of masu salmon (Oncorhynchus masou)
著者	Shimomura, Takahiro ; Nakajima, Takuro ; Horikoshi, Moeri ; Iijima, Anai ; Urabe, Hirokazu ; Mizuno, Shinya ; Hiramatsu, Naoshi ; Hara, Akihiko ; Shimizu, Munetaka
著者名 Shimomura, Takahiro
著者名 Nakajima, Takuro
著者名 Horikoshi, Moeri
著者名 Iijima, Anai
著者名 Urabe, Hirokazu
著者名 Mizuno, Shinya
e-Rad_Researcher 10443920 著者名 Hiramatsu, Naoshi
e-Rad_Researcher 40091483 著者名 Hara, Akihiko
e-Rad_Researcher 90431337 著者名 Shimizu, Munetaka
言語	英語
キーワード	Insulin-like growth factor-I
	Salmon
	Smoltification
	Gill
	Na+,K+-ATPase
	Serum
発行日	2012-09-01
出版者	Elsevier
収録物名	General and Comparative Endocrinology
巻(号)	178(2)
ページ	427-435
抄録	We established profiles of insulin-like growth factor (IGF)-I mRNA in the liver, gill and white muscle and circulating IGF-I during smoltification of hatchery-reared masu salmon, and compared with that of gill Na+,K+-ATPase (NKA) activity. Gill NKA activity peaked in May, and dropped in June. Liver igf1mRNA was high in March and decreased to low levels thereafter. Gill igf1 increased from March, maintained its high levels during April and May and decreased in June. Muscle igf1 mRNA levels were relatively high during January and April when water temperature was low. Serum IGF-I continuously increased from March through June. Serum IGF-I during March and May showed a positive correlation with NKA activity, although both were also related to fish size. These parameters were standardized with fork length and re-analyzed. As a result, serum IGF-I and gill igf1 were correlated with NKA activity. On the other hand, samples from desmoltification period (June) that had high serum IGF-I levels and low NKA activity disrupted the relationship. Expression of two IGF-I receptor (igf1r) subtypes in the gill decreased in June, which could account for the disruption by preventing circulating IGF-I from acting on the gill and retaining it in the blood. The present study suggests that the increase in gill NKA activity in the course of smoltification of masu salmon was supported by both endocrine and local IGF-I, and the decrease during desmoltification in freshwater was due at least in part to the down-regulation of gill IGF-I receptors.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0016-6480
関連情報	PMID 22749841
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ygcen.2012.06.011