Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner

Koizumi, Shin-ichi; Masuko, Kazutaka; Wakita, Daiko; Tanaka, Sachi; Mitamura, Rieko; Kato, Yoshihiro; Tabata, Homare; Nakahara, Masahiro; Kitamura, Hidemitsu; Nishimura, Takashi

Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner

Koizumi, Shin-ichi; Masuko, Kazutaka; Wakita, Daiko et al.

Cellular Immunology, 2012, 276(1-2), 153-161

Permalink : https://hdl.handle.net/2115/50107

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アクセス権	open access
URI	https://hdl.handle.net/2115/50107
タイトル	Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner
著者	Koizumi, Shin-ichi ; Masuko, Kazutaka ; Wakita, Daiko ; Tanaka, Sachi ; Mitamura, Rieko ; Kato, Yoshihiro ; Tabata, Homare ; Nakahara, Masahiro ; Kitamura, Hidemitsu ; Nishimura, Takashi
著者名 Koizumi, Shin-ichi
著者名 Masuko, Kazutaka
著者名 Wakita, Daiko
著者名 Tanaka, Sachi
著者名 Mitamura, Rieko
著者名 Kato, Yoshihiro
著者名 Tabata, Homare
著者名 Nakahara, Masahiro
e-Rad_Researcher 40360531 著者名 Kitamura, Hidemitsu
e-Rad_Researcher 30143001 著者名 Nishimura, Takashi
言語	英語
キーワード	Dendritic cells
	Toll-like receptor
	Adjuvant
	Cytotoxic T lymphocytes
	Type-1 immunity
	Cancer immunotherapy
発行日	2012-03
出版者	Elsevier
収録物名	Cellular Immunology
巻(号)	276(1-2)
ページ	153-161
抄録	Type-1 immunity plays a crucial role in host defense against various tumors and infectious diseases. Here, we first demonstrated that extract of Larix Leptolepis (ELL), one of the most popular timbers at Hokkaido area in Japan, strongly activated Type-1 immunity. ELL induced production of Type-1 cytokines such as IL-12 and TNF-α from bone marrow-derived dendritic cells (BMDCs) in TLR2- and TLR4-dependent manner and remarkably up-regulated the expression of MHC and co-stimulatory molecules. In addition, antigen-specific CTLs were significantly augmented by the combined administration of ELL, antigen and BMDCs. Finally, we revealed that combination therapy using ELL, antigen and BMDCs significantly inhibited the growth of established tumor in mouse model. Thus, these findings suggested that ELL would be a novel adjuvant for inducing an activation of Type-1-dependent immunity including activation of BMDCs and induction of tumor-specific CTLs, which is applicable to the therapy of cancer and infectious diseases.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0008-8749
関連情報	PMID 22677561
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.cellimm.2012.05.002