Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET

Zhao, Songji; Kuge, Yuji; Yi, Min; Zhao, Yan; Hatano, Toshiyuki; Magota, Keiichi; Nishijima, Ken-ichi; Kohanawa, Masashi; Tamaki, Nagara

Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET

Zhao, Songji; Kuge, Yuji; Yi, Min et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2011, 38(10), 1876-1886

Permalink : https://hdl.handle.net/2115/50146

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アクセス権	open access
URI	https://hdl.handle.net/2115/50146
タイトル	Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET
著者	Zhao, Songji ; Kuge, Yuji ; Yi, Min ; Zhao, Yan ; Hatano, Toshiyuki ; Magota, Keiichi ; Nishijima, Ken-ichi ; Kohanawa, Masashi ; Tamaki, Nagara
e-Rad_Researcher 80374239 著者名 Zhao, Songji
e-Rad_Researcher 70321958 著者名 Kuge, Yuji
著者名 Yi, Min
著者名 Zhao, Yan
著者名 Hatano, Toshiyuki
e-Rad_Researcher 20636419 著者名 Magota, Keiichi
著者名 Nishijima, Ken-ichi
e-Rad_Researcher 90234806 著者名 Kohanawa, Masashi
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
言語	英語
キーワード	Dynamic 11C-MET PET
	Granuloma
	Inflammation
	Tumor
	Rat
発行日	2011-10
出版者	Springer Berlin / Heidelberg
収録物名	European Journal of Nuclear Medicine and Molecular Imaging
巻(号)	38(10)
ページ	1876-1886
抄録	Purpose: We evaluated whether the dynamic profile of 11C-MET may have an additional value in differentiating malignant tumors from granulomas in experimental rat models by small animal PET. Methods: Rhodococcus aurantiacus and allogenic rat C6-glioma cells were inoculated respectively into the right and left calf muscles to generate a rat model bearing both granulomas and tumors (n = 6). Ten days after the inoculations, dynamic 11C-MET PET was performed by small-animal PET up to 120 min after injection of 11C-MET. The next day, after overnight fasting, the rats were injected with 18F-FDG, and dynamic 18F-FDG PET was performed up to 180 min. The time-activity curves, static images, and mean standardized uptake value (SUV) in the lesions were calculated. Results: 11C-MET uptake in the granuloma showed a slow exponential clearance after an initial distribution, while the uptake in the tumor gradually increased with time. The dynamic pattern of 11C-MET uptake in the granuloma was significantly different from that in the tumor (p < 0.001). In the static analysis of 11C-MET, visual assessment and SUV analysis could not differentiate the tumor from the granuloma in all cases, although the mean SUV in the granuloma (1.48 ± 0.09) was significantly lower than that in the tumor (1.72 ± 0.18, p < 0.01). The dynamic patterns, static images, and mean SUVs of 18F-FDG in the granuloma were similar to those in the tumor (p = NS). Conclusions: Dynamic 11C-MET PET has an additional value for differentiating malignant tumors from granulomatous lesions, which deserve further elucidation in clinical settings.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The original publication is available at www.springerlink.com
PISSN	1619-7070
関連情報	PMID 21732106
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00259-011-1865-2