Identification and expression analysis of the genes involved in serotonin biosynthesis and transduction in the field cricket Gryllus bimaculatus

Watanabe, Takayuki; Sadamoto, Hisayo; Aonuma, Hitoshi

Insect Molecular Biology, 2011, 20(5), 619-635

Permalink : https://hdl.handle.net/2115/50147

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論文情報

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アクセス権
open access
URI
https://hdl.handle.net/2115/50147
タイトル
Identification and expression analysis of the genes involved in serotonin biosynthesis and transduction in the field cricket Gryllus bimaculatus
著者
Watanabe, Takayuki ; Sadamoto, Hisayo ; Aonuma, Hitoshi
著者名
Watanabe, Takayuki
著者名
Sadamoto, Hisayo
e-Rad_Researcher
20333643
著者名
Aonuma, Hitoshi
言語
英語
キーワード
serotonin
tryptophan hydroxylase
phenylalanine-tryptophan hydroxylase
aromatic L-amino acid decarboxylase
serotonin receptors
Gryllus bimaculatus
発行日
2011-10
出版者
Wiley-Blackwell
収録物名
Insect Molecular Biology
巻(号)
20(5)
ページ
619-635
抄録
Serotonin (5-HT) modulates various aspects of behaviours such as aggressive behaviour and circadian behaviour in the cricket. To elucidate the molecular basis of the cricket 5-HT system, we identified 5-HT-related genes in the field cricket Gryllus bimaculatus DeGeer. Complementary DNA of tryptophan hydroxylase (TRH) and phenylalanine-tryptophan hydroxylase (TPH) which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase (AADC) which converts 5-HTP into 5-HT were isolated from a cricket brain cDNA library. In addition, four 5-HT receptor genes (5-HT_[1A], 5-HT_[1B], 5-HT_[2α], and 5-HT7) were identified. Expression analysis of TRH and TPH, which are selectively involved in neuronal and peripheral 5-HT synthesis in Drosophila, suggested that two 5-HT synthesis pathways co-exist in the cricket neuronal tissues. The four of 5-HT receptor genes were expressed in various tissues at differential expression levels, suggesting that the 5-HT system is widely distributed in the cricket.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The definitive version is available at http://onlinelibrary.wiley.com/
PISSN
0962-1075
関連情報
PMID
21699597
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1111/j.1365-2583.2011.01093.x