Expression of Bim, Noxa, and Puma in non-small cell lung cancer

Sakakibara-Konishi, Jun; Oizumi, Satoshi; Kikuchi, Junko; Kikuchi, Eiki; Mizugaki, Hidenori; Kinoshita, Ichiro; Dosaka-Akita, Hirotoshi; Nishimura, Masaharu

Expression of Bim, Noxa, and Puma in non-small cell lung cancer

Sakakibara-Konishi, Jun; Oizumi, Satoshi; Kikuchi, Junko et al.

BMC Cancer, 2012, 12, 286

Permalink : https://hdl.handle.net/2115/50287

このアイテムのアクセス数:1,404件（2026-10-07 21:46 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
BMCC12_286	pdf	1.62 MB	1,204

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/50287
タイトル	Expression of Bim, Noxa, and Puma in non-small cell lung cancer
著者	Sakakibara-Konishi, Jun ; Oizumi, Satoshi ; Kikuchi, Junko ; Kikuchi, Eiki ; Mizugaki, Hidenori ; Kinoshita, Ichiro ; Dosaka-Akita, Hirotoshi ; Nishimura, Masaharu
e-Rad_Researcher 50374278 著者名 Sakakibara-Konishi, Jun
e-Rad_Researcher 10421968 著者名 Oizumi, Satoshi
著者名 Kikuchi, Junko
著者名 Kikuchi, Eiki
著者名 Mizugaki, Hidenori
e-Rad_Researcher 40343008 著者名 Kinoshita, Ichiro
著者名 Dosaka-Akita, Hirotoshi
e-Rad_Researcher 00208224 著者名 Nishimura, Masaharu
言語	英語
発行日	2012-07-12
出版者	BioMed Central
収録物名	BMC Cancer
巻(号)	12
ページ	286
抄録	Background: The BH3-only members of the Bcl-2 protein family have been proposed to play a key role in the control of apoptosis and in the initiation of the apoptotic pathways. In this study, we evaluated the expression of Bim, Noxa, and Puma in non-small cell lung cancer (NSCLC). Methods: A total of 135 surgically resected NSCLCs were immunohistochemically assessed for Bim, Noxa, and Puma expression. The immunoscores were determined, and then its correlation with either the clinicopathological variables or the survival outcomes were analyzed. Results: Immunohistochemical reactivity for Bim, Noxa, and Puma was detected in the cytoplasm of the tumor cells. Bim expression was associated with several clinicopathological factors, including sex (p < 0.001), smoking habit (p = 0.03), pathological histology (p = 0.001), pathological T stage (p = 0.03), pathological disease stage (p = 0.02), and differentiation of tumor (p < 0.001). Multivariate logistic regression analysis showed a significant correlation between low Bim expression and squamous cell carcinoma (p = 0.04), in addition to a correlation between high Bim expression and well differentiated tumors (p = 0.02). Analysis of cellular biological expression demonstrated a link between low Bim expression and high Ki67. While Noxa expression was also shown to be correlated with both smoking habit (p = 0.02) and the pathological histology (p = 0.03), there was no strong association observed between the expression and the clinical features when they were examined by a multivariate logistic regression analysis. No correlations were noted between Puma expression and any of the variables. Our analyses also indicated that the expression levels of the BH3-only proteins were not pertinent to the survival outcome. Conclusions: The current analyses demonstrated that Bim expression in the NSCLCs was associated with both squamous cell carcinoma histology and tumor proliferation.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 2.0 Generic
PISSN	1471-2407
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/1471-2407-12-286