Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells

Song, Ning; Boku, Shuken; Nakagawa, Shin; Kato, Akiko; Toda, Hiroyuki; Takamura, Naoki; Omiya, Yuki; Kitaichi, Yuji; Inoue, Takeshi; Koyama, Tsukasa

Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells

Song, Ning; Boku, Shuken; Nakagawa, Shin et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2012, 38(2), 183-189

Permalink : https://hdl.handle.net/2115/50363

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アクセス権	open access
URI	https://hdl.handle.net/2115/50363
タイトル	Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells
著者	Song, Ning ; Boku, Shuken ; Nakagawa, Shin ; Kato, Akiko ; Toda, Hiroyuki ; Takamura, Naoki ; Omiya, Yuki ; Kitaichi, Yuji ; Inoue, Takeshi ; Koyama, Tsukasa
著者名 Song, Ning
e-Rad_Researcher 60455665 著者名 Boku, Shuken
e-Rad_Researcher 60360905 著者名 Nakagawa, Shin
著者名 Kato, Akiko
著者名 Toda, Hiroyuki
著者名 Takamura, Naoki
著者名 Omiya, Yuki
著者名 Kitaichi, Yuji
e-Rad_Researcher 70250438 著者名 Inoue, Takeshi
e-Rad_Researcher 10113557 著者名 Koyama, Tsukasa
言語	英語
キーワード	Apoptosis
	Hippocampus
	Dentate gyrus
	Adult neurogenesis
	Bcl-2
発行日	2012-08-07
出版者	Elsevier
収録物名	Progress in Neuro-Psychopharmacology and Biological Psychiatry
巻(号)	38(2)
ページ	183-189
抄録	Adult neurogenesis in dentate gyrus (DG) is involved in the action mechanism of mood stabilizers. However, it is poorly understood how mood stabilizers affect adult neurogenesis in DG. Neurogenesis consists of proliferation, survival (anti-apoptosis) and differentiation of neural precursor cells in adult DG. Using in vitro culture of adult rat DG-derived neural precursor cells (ADP), we have already shown that four mood stabilizers, such as lithium (Li), valproate (VPA), carbamazepine (CBZ) and lamotrigine (LTG), commonly decrease staurosporine (STS)-induced apoptosis of ADP. These suggest that the common anti-apoptotic effect of mood stabilizers could be involved in mood-stabilizing effects. Past studies have shown that Li and VPA increase the expression of Bcl-2, an anti-apoptotic gene. In addition, it has been shown that Li decreases the expression of p53, which plays a prominent role in apoptosis and regulates the expression of Bcl-2. Therefore, p53 and Bcl-2 can be considered to mediate the common anti-apoptotic effects of Li, VPA, CBZ and LTG. To elucidate the molecular mechanism underlying the common anti-apoptotic effects of mood stabilizers, we investigated the effects of Li, VPA, CBZ and LTG on STS-induced expression changes of p53, Bcl-2 and other p53-related molecules using SH-SY5Y cells as a model of neural precursor-like cells. STS increased the expression of p53 and decreased that of Bcl-2. These effects of STS on p53 and Bcl-2 are restored by all of Li, VPA, CBZ and LTG. In addition, p53 overexpression decreased the expression of Bcl-2. Taken together, these results suggest that p53 and Bcl-2 may be involved in a part of mood-stabilizing effects.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0278-5846
関連情報	PMID 22484386
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.pnpbp.2012.03.006