Glucocorticoids and lithium in adult hippocampal neurogenesis

Boku, Shuken; Nakagawa, Shin; Koyama, Tsukasa

Vitamins and hormones, 2010, 82, 421-431

Permalink : https://hdl.handle.net/2115/50394

このアイテムのアクセス数:1,344件（2026-02-18 20:54 集計）

閲覧可能ファイル 

ファイル フォーマット サイズ 閲覧回数 説明
VH82_421-431 pdf 241 KB 1,567

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権
open access
URI
https://hdl.handle.net/2115/50394
タイトル
Glucocorticoids and lithium in adult hippocampal neurogenesis
著者
Boku, Shuken ; Nakagawa, Shin ; Koyama, Tsukasa
e-Rad_Researcher
60455665
著者名
Boku, Shuken
e-Rad_Researcher
60360905
著者名
Nakagawa, Shin
e-Rad_Researcher
10113557
著者名
Koyama, Tsukasa
言語
英語
キーワード
Cyclin D1
Dentate gyrus
Dexamethasone
GSK-3β-catenin
Mood disorder
Neural precursor cell
発行日
2010
収録物名
Vitamins and hormones
巻(号)
82
ページ
421-431
抄録
Adult hippocampal neurogenesis is decreased in rodent models for stress-related disorders partly through an elevated level of glucocorticoids (GCs). On the other hand, lithium (Li), a mood stabilizer and an inhibitor of GSK-3beta, increases adult hippocampal neurogenesis. However, it remains unclear whether GCs-induced decrease can be recovered by Li or not. Recently we established the culture system of adult rat dentate gyrus-derived neural precursor cell (ADP) and examined GCs and Li actions on ADP proliferation. GCs decreased ADP proliferation and Li recovered it. Both cyclin Dl expression and nuclear beta-catenin are also reciprocally regulated by GCs and Li. In addition, GCs activated GSK-3beta. Therefore, GSK-3beta/beta-catenin pathway may be important in the reciprocal actions of GCs and Li on ADP proliferation. In this manuscript, we review the past literature and our study and summarize what is currently known about the effects of GCs and Li on adult hippocampal neurogenesis.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0083-6729
関連情報
PMID
20472150
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/S0083-6729(10)82021-7