open access

https://hdl.handle.net/2115/50771

Clinical features of spinal cord sarcoidosis : analysis of 17 neurosarcoidosis patients

英語

Angiotensin-converting enzyme

2011-12

Springer-Verlag

Journal of Neurology

258(12)

2163-2167

The diagnosis of neurosarcoidosis is often difficult; the imaging signs of spinal cord sarcoidosis sometimes mimic those of cervical spondylotic myelopathy, which is common in elderly persons. We examined the characteristics of spinal cord sarcoidosis in Japanese patients with neurosarcoidosis. This case series identified patients with neurosarcoidosis at 4 general hospitals and 1 university hospital from April 1998 to September 2010. All diagnoses were based on the diagnostic criteria proposed by Zajicek et al. Seventeen patients (9 men and 8 women) were involved: 6 patients with spinal cord lesions accompanied by cervical spondylosis, 5 with cerebral lesions, 3 with cranial nerve lesions, 2 with meningitis, and 1, with nerve root lesions. Patients with spinal cord sarcoidosis had a higher onset age, longer duration from onset to diagnosis, reduced leukocytosis in the cerebrospinal fluid (CSF), and lower angiotensin-converting enzyme (ACE) levels in the CSF. The results of this study indicate that diagnosis of spinal cord sarcoidosis requires careful evaluation.

学術雑誌論文

Accepted Manuscript

The original publication is available at www.springerlink.com

0340-5354