Ferrous Ferric Chloride Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection in Mice

Yimin; Tao, Huirong; Kohanawa, Masashi et al.

Biological and Pharmaceutical Bulletin, 2012, 35(12), 2214-2223

Permalink : https://hdl.handle.net/2115/51074

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アクセス権
open access
URI
https://hdl.handle.net/2115/51074
タイトル
Ferrous Ferric Chloride Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection in Mice
著者
Yimin ; Tao, Huirong ; Kohanawa, Masashi ; Zhao, Songji ; Kuge, Yuji ; Tamaki, Nagara
e-Rad_Researcher
40292007
著者名
Yimin
著者名
Tao, Huirong
e-Rad_Researcher
90234806
著者名
Kohanawa, Masashi
e-Rad_Researcher
80374239
著者名
Zhao, Songji
e-Rad_Researcher
70321958
著者名
Kuge, Yuji
e-Rad_Researcher
30171888
著者名
Tamaki, Nagara
言語
英語
キーワード
Pairogen
ferrous ferric chloride
immuno-inflammatory response
Rhodococcus aurantiacus
redox state
mouse
発行日
2012-12
出版者
Pharmaceutical Society of Japan
収録物名
Biological and Pharmaceutical Bulletin
巻(号)
35(12)
ページ
2214-2223
抄録
The healthy drink Pairogen is mainly composed of ferrous ferric chloride water that reportedly changes the status of intracellular water from oxidative to antioxidative. Here, we investigated whether Pairogen affects host immune function in a murine model of granulomatous inflammation in response to Rhodococcus aurantiacus (R. aurantiacus) infection. Longitudinal ingestion of Pairogen markedly improved the survival of infected mice in a concentration-dependent manner. Compared to mice received water, mice that ingested 10-fold-diluted Pairogen displayed rapid bacterial elimination, decreased production of tumor necrosis factor (TNF)-α and interleukin (IL)-6, and high levels of IL-10 in organs during the initial phase of infection. Moreover, histological studies showed significant reduction in the number and size of granulomas as well as amelioration of oxidative stress in the livers of mice ingested 10-fold-diluted Pairogen at 14d post-infection. These characteristics were further pronounced in first-generation (F1) mice that also ingested 10-fold-diluted Pairogen. Following stimulation with heat-killed R. aurantiacus, the production of TNF-α, IL-6, and IL-10 by macrophages from F1 mice was similar to that detected in vivo, while their gene expression levels in these cells were significantly lower than the levels in macrophages from mice received water. Heat-killed R. aurantiacus also induced the expression of heme oxygenase-1 mRNA in the cells from F1 mice. Taken together, these results indicate that Pairogen contributes to the negative regulation of the immuno-inflammatory response to R. aurantiacus infection in mice by modulating the cellular redox state. Longitudinal ingestion of Pairogen further enhances the defense function in mouse progeny.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.b12-00672