Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning

Mizuta, Masahiro; Date, Hiroyuki; Takao, Seishin; Kishimoto, Naoki; Sutherland, Kenneth L.; Onimaru, Rikiya; Shirato, Hiroki

Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning

Mizuta, Masahiro; Date, Hiroyuki; Takao, Seishin et al.

Medical Physics, 2012, 39(11), 6791-6795

Permalink : https://hdl.handle.net/2115/51088

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アクセス権	open access
URI	https://hdl.handle.net/2115/51088
タイトル	Graphical representation of the effects on tumor and OAR for determining the appropriate fractionation regimen in radiation therapy planning
著者	Mizuta, Masahiro ; Date, Hiroyuki ; Takao, Seishin ; Kishimoto, Naoki ; Sutherland, Kenneth L. ; Onimaru, Rikiya ; Shirato, Hiroki
e-Rad_Researcher 70174026 著者名 Mizuta, Masahiro
e-Rad_Researcher 10197600 著者名 Date, Hiroyuki
e-Rad_Researcher 10614216 著者名 Takao, Seishin
著者名 Kishimoto, Naoki
e-Rad_Researcher 30451446 著者名 Sutherland, Kenneth L.
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	radiation therapy
	radiation effect
	dose fractionation
	organ at riskl
	inear-quadratic model
発行日	2012-11
出版者	American Association of Physicists in Medicine
収録物名	Medical Physics
巻(号)	39(11)
ページ	6791-6795
抄録	PURPOSE: The authors propose a graphical representation of the relation between the effect on the tumor and the damage effect on an organ at risk (OAR) against the irradiation dose, as an aid for choosing an appropriate fractionation regimen. METHODS: The graphical relation is depicted by the radiation effect on the tumor E(1) versus that on an OAR E(0). By observing the features of the E(1) vs E(0) relation curve, i.e., convex or concave shape, one can judge whether multifractionation is better or not. This method is applied to the linear-quadratic model (with α and β parameters) as an example. Further, the method is extended to the general case for nonuniform dose distribution to the OAR, which is frequently seen in clinical situations. RESULTS: The criterion for selecting multi- or hypofractionation is based on the relation between the dose for the OAR and the α∕β ratio of the OAR to the tumor. It is also shown that the graphical relation enables us to estimate the final effect after multifractionated treatment by plotting a tangent line on the curve. CONCLUSIONS: The graphical representation method is of use for improving planning in radiotherapy by determining the effective fractionation scheme.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0094-2405
関連情報	PMID 23127073
関連情報	URI http://online.medphys.org/resource/1/mphya6/v39/i11/p6791_s1
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1118/1.4757580