[18F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer

Yasuda, Koichi; Onimaru, Rikiya; Okamoto, Shozo; Shiga, Tohru; Katoh, Norio; Tsuchiya, Kazuhiko; Suzuki, Ryusuke; Takeuchi, Wataru; Kuge, Yuji; Tamaki, Nagara; Shirato, Hiroki

[18F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer

Yasuda, Koichi; Onimaru, Rikiya; Okamoto, Shozo et al.

International Journal of Radiation Oncology*Biology*Physics, 2013, 85(1), 142-147

Permalink : https://hdl.handle.net/2115/51373

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アクセス権	open access
URI	https://hdl.handle.net/2115/51373
タイトル	[18F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer
著者	Yasuda, Koichi ; Onimaru, Rikiya ; Okamoto, Shozo ; Shiga, Tohru ; Katoh, Norio ; Tsuchiya, Kazuhiko ; Suzuki, Ryusuke ; Takeuchi, Wataru ; Kuge, Yuji ; Tamaki, Nagara ; Shirato, Hiroki
e-Rad_Researcher 00431362 著者名 Yasuda, Koichi
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
著者名 Okamoto, Shozo
e-Rad_Researcher 80374495 著者名 Shiga, Tohru
著者名 Katoh, Norio
著者名 Tsuchiya, Kazuhiko
e-Rad_Researcher 00400052 著者名 Suzuki, Ryusuke
著者名 Takeuchi, Wataru
e-Rad_Researcher 70321958 著者名 Kuge, Yuji
e-Rad_Researcher 30171888 著者名 Tamaki, Nagara
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	radiotherapy
	hypoxia
	positron emission tomography
	18F-fluoromisonidazole
	semiconductor
発行日	2013-01-01
出版者	Elsevier
収録物名	International Journal of Radiation OncologyBiologyPhysics
巻(号)	85(1)
ページ	142-147
抄録	Purpose: The impact of a new type of positron emission tomography with semiconductor detectors (New PET) on an 18F-fluoromisonidazole (FMISO)-guided intensity-modulated radiation therapy (IMRT) plan was investigated by comparing the plan with the use of a state-of-the-art PET/computed tomography system (PET/CT) in nasopharyngeal cancer (NPC) patients. Methods and Materials: Twenty-four patients with non-NPC malignant tumors (control group) and 16 patients with NPC were subjected to FMISO-PET. The threshold of the tumor-to-muscle (T/M) ratio in each PET scan was calculated. The hypoxic volume within the gross tumor volume was determined using each PET ([NewPET]GTVh and [PET/CT]GTVh, respectively). Dose-escalation IMRT plans prescribing 84Gy to each GTVh were carried out. Results: The threshold of the T/M ratio was calculated to be 1.35 for New PET and 1.23 for PET/CT. The mean volume of [NewPET]GTVh was significantly smaller than that of [PET/CT]GTVh (1.5±1.6cc vs. 4.7±4.6cc, respectively, P =0.0020). The dose-escalation IMRT plans using New PET were superior in dose distribution to those using PET/CT. Dose escalation was possible in all 10 New PET-guided plans but not in one PET/CT-guided plan, because the threshold dose to the brainstem was exceeded. Conclusion: New PET was suggested to be useful for accurate dose escalation in FMISO-guided IMRT for patients with NPC.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0360-3016
関連情報	PMID 22583608
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.ijrobp.2012.03.029