Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

Sano, Yoshitake; Nakaya, Tadashi; Pedrini, Steve; Takeda, Shizu; Iijima-Ando, Kanae; Iijima, Koichi; Mathews, Paul M; Itohara, Shigeyoshi; Gandy, Sam; Suzuki, Toshiharu

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

Sano, Yoshitake; Nakaya, Tadashi; Pedrini, Steve et al.

PloS one, 2006, 1, e51

Permalink : https://hdl.handle.net/2115/51693

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アクセス権	open access
URI	https://hdl.handle.net/2115/51693
タイトル	Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.
著者	Sano, Yoshitake ; Nakaya, Tadashi ; Pedrini, Steve ; Takeda, Shizu ; Iijima-Ando, Kanae ; Iijima, Koichi ; Mathews, Paul M ; Itohara, Shigeyoshi ; Gandy, Sam ; Suzuki, Toshiharu
著者名 Sano, Yoshitake
e-Rad_Researcher 50374559 著者名 Nakaya, Tadashi
著者名 Pedrini, Steve
著者名 Takeda, Shizu
著者名 Iijima-Ando, Kanae
著者名 Iijima, Koichi
著者名 Mathews, Paul M
e-Rad_Researcher 60252524 著者名 Itohara, Shigeyoshi
著者名 Gandy, Sam
e-Rad_Researcher 80179233 著者名 Suzuki, Toshiharu
言語	英語
発行日	2006
出版者	The Public Library of Science
収録物名	PloS one
巻(号)	1
ページ	e51
抄録	Amyloid-beta peptide species ending at positions 40 and 42 (Abeta40, Abeta42) are generated by the proteolytic processing of the Alzheimer's amyloid precursor protein (APP). Abeta peptides accumulate in the brain early in the course of Alzheimer's disease (AD), especially Abeta42. The cytoplasmic domain of APP regulates intracellular trafficking and metabolism of APP and its carboxyl-terminal fragments (CTFalpha, CTFbeta). The role of protein phosphorylation in general, and that of the phosphorylation state of APP at threonine-668 (Thr668) in particular, has been investigated in detail by several laboratories (including our own). Some investigators have recently proposed that the phosphorylation state of Thr668 plays a pivotal role in governing brain Abeta levels, prompting the current study.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
PISSN	1932-6203
関連情報	PMID 17183681
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0000051