Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test

Hata, Tamotsu; Kato, Mototsugu; Kudo, Takahiko; Nishida, Mutsumi; Nishida, Urara; Imai, Aki; Yoshida, Takeshi; Hirota, Jyojyo; Kamada, Go; Ono, Shouko; Nakagawa, Manabu; Nakagawa, Soichi; Shimizu, Yuichi; Takeda, Hiroshi; Asaka, Masahiro

Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test

Hata, Tamotsu; Kato, Mototsugu; Kudo, Takahiko et al.

Digestion, 2013, 87(1), 34-39

Permalink : https://hdl.handle.net/2115/52030

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アクセス権	open access
URI	https://hdl.handle.net/2115/52030
タイトル	Comparison of Gastric Relaxation and Sensory Functions between Functional Dyspepsia and Healthy Subjects Using Novel Drinking-Ultrasonography Test
著者	Hata, Tamotsu ; Kato, Mototsugu ; Kudo, Takahiko ; Nishida, Mutsumi ; Nishida, Urara ; Imai, Aki ; Yoshida, Takeshi ; Hirota, Jyojyo ; Kamada, Go ; Ono, Shouko ; Nakagawa, Manabu ; Nakagawa, Soichi ; Shimizu, Yuichi ; Takeda, Hiroshi ; Asaka, Masahiro
著者名 Hata, Tamotsu
e-Rad_Researcher 60271673 著者名 Kato, Mototsugu
著者名 Kudo, Takahiko
著者名 Nishida, Mutsumi
著者名 Nishida, Urara
著者名 Imai, Aki
著者名 Yoshida, Takeshi
著者名 Hirota, Jyojyo
著者名 Kamada, Go
著者名 Ono, Shouko
著者名 Nakagawa, Manabu
著者名 Nakagawa, Soichi
e-Rad_Researcher 90333608 著者名 Shimizu, Yuichi
著者名 Takeda, Hiroshi
e-Rad_Researcher 10113507 著者名 Asaka, Masahiro
言語	英語
キーワード	Functional gastroduodenal disorders
	Drink test
	Ultrasonography
	Gastric accommodation
	Gastric emptying
	Visceral hypersensitivity
発行日	2013-01
出版者	Karger
収録物名	Digestion
巻(号)	87(1)
ページ	34-39
抄録	Background: Functional dyspepsia (FD) is a heterogeneous disease characterized by various upper abdominal symptoms. The major mechanism of FD includes impaired fundic accommodation, delayed gastric emptying, and visceral hypersensitivity. We developed a novel drinking-ultrasonography test to combine a drink test with ultrasonography to assess gastric motility and sensory function of FD patients. Method: Subjects were 20 healthy volunteers and 26 successive FD patients according to the Rome III criteria. The subjects ingested 200 ml of water at 2-min intervals 4 times (total 800 ml) through a straw. The maximum cross section of the proximal stomach was visualized before water intake, after each water intake, and 5 and 10 min after the completion of drinking using extracorporeal ultrasonography. Abdominal symptoms were evaluated using the visual analog scale (VAS) a total of 5 times. Results: The mean cross-sectional area of the fornix after 800-ml water intake was significantly lower in the FD group compared with the control group. In the FD group, marked abdominal symptoms developed immediately after initiation of water intake and VAS Score differed significantly (p < 0.01) between the control and FD groups at each time point. Conclusion: We developed the drinking-ultrasonography test and this novel test revealed abnormalities in gastric accommodation and sensation in patients with FD compared with healthy controls. This approach can be readily performed and allows the simultaneous evaluation of gastric accommodation, emptying and sensation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	© 2013 S. Karger AG, Basel
PISSN	0012-2823
関連情報	PMID 23343967
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1159/000343935