A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine

Shinoki, Aki; Lang, Weeranuch; Thawornkuno, Charin; Kang, Hee-Kwon; Kumagai, Yuya; Okuyama, Masayuki; Mori, Haruhide; Kimura, Atsuo; Ishizuka, Satoshi; Hara, Hiroshi

A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine

Shinoki, Aki; Lang, Weeranuch; Thawornkuno, Charin et al.

Food Chemistry, 2013, 136(2), 293-296

Permalink : https://hdl.handle.net/2115/52124

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アクセス権	open access
URI	https://hdl.handle.net/2115/52124
タイトル	A novel mechanism for the promotion of quercetin glycoside absorption by megalo α-1,6-glucosaccharide in the rat small intestine
著者	Shinoki, Aki ; Lang, Weeranuch ; Thawornkuno, Charin ; Kang, Hee-Kwon ; Kumagai, Yuya ; Okuyama, Masayuki ; Mori, Haruhide ; Kimura, Atsuo ; Ishizuka, Satoshi ; Hara, Hiroshi
著者名 Shinoki, Aki
著者名 Lang, Weeranuch
著者名 Thawornkuno, Charin
著者名 Kang, Hee-Kwon
著者名 Kumagai, Yuya
e-Rad_Researcher 00344490 著者名 Okuyama, Masayuki
e-Rad_Researcher 80241363 著者名 Mori, Haruhide
e-Rad_Researcher 90186312 著者名 Kimura, Atsuo
e-Rad_Researcher 00271627 著者名 Ishizuka, Satoshi
e-Rad_Researcher 70198894 著者名 Hara, Hiroshi
言語	英語
キーワード	α-1,6-Glucosaccharide
	Quercetin glycoside
	Absorption
	Rats
発行日	2013-01-15
出版者	Elsevier
収録物名	Food Chemistry
巻(号)	136(2)
ページ	293-296
抄録	The presence of α-1,6-glucosaccharide enhances absorption of water-soluble quercetin glycosides, a mixture of quercetin-3-O-β-D-glucoside (Q3G, 31.8%), mono (23.3%), di (20.3%) and more D-glucose adducts with α-1,4-linkage to D-glucose moiety of Q3G, in a ligated small intestinal loop of anesthetized rats. We enzymatically prepared α-1,6-glucosaccharides with different degrees of polymerization (DP) and separated them into a megaloisomaltosaccharide-containing fraction (M-IM, average DP = 11.0) and an oligoisomaltosaccharide-containing fraction (O-IM, average DP = 3.6). Luminal injection of either saccharide fractions promoted the absorption of total quercetin-derivatives from the small intestinal segment and this effect was greater for M-IM than O-IM addition. M-IM also increased Q3G, but not the quercetin aglycone, concentration in the water-phase of the luminal contents more strongly than O-IM. The enhancement of Q3G solubilization in the luminal contents may be responsible for the increases in the quercetin glucoside absorption promoted by α-1,6-glucosaccharides, especially M-IM. These results suggest that the ingestion of α-1,6-glucosaccharides promotes Q3G bioavailability.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0308-8146
関連情報	PMID 23122060
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.foodchem.2012.08.028