Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds

Kato, Eisuke; Kawabata, Jun

Bioorganic & Medicinal Chemistry Letters, 2010, 20(15), 4333-4336

Permalink : https://hdl.handle.net/2115/52134

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アクセス権	open access
URI	https://hdl.handle.net/2115/52134
タイトル	Glucose uptake enhancing activity of puerarin and the role of C-glucoside suggested from activity of related compounds
著者	e-Rad_Researcher 40466446 著者名 Kato, Eisuke
著者	e-Rad_Researcher 60142197 著者名 Kawabata, Jun
言語	英語
キーワード	Puerarin
	Isoflavone
	Diabetes mellitus
	PPARγ
	Glucose uptake
発行日	2010-08-01
出版者	Elsevier
収録物名	Bioorganic & Medicinal Chemistry Letters
巻(号)	20(15)
ページ	4333-4336
抄録	Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance glucose uptake into the insulin sensitive cell and is thought to be a candidate for treatment of diabetes mellitus. We synthesized 1 and several derivatives to apply for the structure-activity relationship study. The result against 3T3-L1 adipocyte indicated that the C-glucoside part of 1 is unconcerned in its activity when tested in vitro and the main structure responsible for its activity was the isoflavone moiety.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0960-894X
関連情報	PMID 20605096
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bmcl.2010.06.077