Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha

Kato, Eisuke; Nakagomi, Ryo; Gunawan-Puteri, Maria D. P. T.; Kawabata, Jun

Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha

Kato, Eisuke; Nakagomi, Ryo; Gunawan-Puteri, Maria D. P. T. et al.

Food Chemistry, 2013, 136(3-4), 1239-1242

Permalink : https://hdl.handle.net/2115/52136

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論文情報

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アクセス権	open access
URI	https://hdl.handle.net/2115/52136
タイトル	Identification of hydroxychavicol and its dimers, the lipase inhibitors contained in the Indonesian spice, Eugenia polyantha
著者	Kato, Eisuke ; Nakagomi, Ryo ; Gunawan-Puteri, Maria D. P. T. ; Kawabata, Jun
e-Rad_Researcher 40466446 著者名 Kato, Eisuke
著者名 Nakagomi, Ryo
著者名 Gunawan-Puteri, Maria D. P. T.
e-Rad_Researcher 60142197 著者名 Kawabata, Jun
言語	英語
キーワード	Eugenia polyantha
	Pancreatic lipase inhibitor
	Obesity
	Spice
	Jamu
発行日	2013-02-15
出版者	Elsevier
収録物名	Food Chemistry
巻(号)	136(3-4)
ページ	1239-1242
抄録	Inhibition of pancreatic lipase is effective for a prevention of obesity. Eugenia polyantha is a tropical tree whose leaves are known as a spice and also as an ingredient for Jamu, the traditional medicine of Indonesia. We found inhibitory activity against pancreatic lipase in the extract of E. polyantha leaves. Purification of the active principals resulted in isolation of hydroxychavicol, and two structurally new dimers. All of the isolated compounds showed inhibitory activity against the porcine pancreatic lipase and high content of hydroxychavicol (1.83 wt%) indicated this compound to be responsible for the majority of inhibitory activity of E. polyantha extract. Furthermore, hydroxychavicol is reported to possess anti-carcinogenic, anti-oxidant, anti-microbial and anti-inflammatory activity which is related to traditional usage of this plant. These results offer this plant as an attractive material for treating various health problems including obesity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0308-8146
関連情報	PMID 23194519
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.foodchem.2012.09.013