Characterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal

Poudel, Ajay; Maharjan, Bhagwan; Nakajima, Chie; Fukushima, Yukari; Pandey, Basu D.; Beneke, Antje; Suzuki, Yasuhiko

Characterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal

Poudel, Ajay; Maharjan, Bhagwan; Nakajima, Chie et al.

Tuberculosis, 2013, 93(1), 84-88

Permalink : https://hdl.handle.net/2115/52260

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アクセス権	open access
URI	https://hdl.handle.net/2115/52260
タイトル	Characterization of extensively drug-resistant Mycobacterium tuberculosis in Nepal
著者	Poudel, Ajay ; Maharjan, Bhagwan ; Nakajima, Chie ; Fukushima, Yukari ; Pandey, Basu D. ; Beneke, Antje ; Suzuki, Yasuhiko
著者名 Poudel, Ajay
著者名 Maharjan, Bhagwan
e-Rad_Researcher 60435964 著者名 Nakajima, Chie
著者名 Fukushima, Yukari
著者名 Pandey, Basu D.
著者名 Beneke, Antje
e-Rad_Researcher 90206540 著者名 Suzuki, Yasuhiko
言語	英語
キーワード	XDR
	Tuberculosis
	Nepal
発行日	2013-01
出版者	Elsevier
収録物名	Tuberculosis
巻(号)	93(1)
ページ	84-88
抄録	The emergence of extensively drug-resistant tuberculosis (XDR-TB) has raised public health concern for global control of TB. Although molecular characterization of drug resistance-associated mutations in multidrug-resistant isolates in Nepal has been made, mutations in XDR isolates and their genotypes have not been reported previously. In this study, we identified and characterized 13 XDR Mycobacterium tuberculosis isolates from clinical isolates in Nepal. The most prevalent mutations involved in rifampicin, isoniazid, ofloxacin, and kanamycin/capreomycin resistance were Ser531Leu in rpoB gene (92.3%), Ser315Thr in katG gene (92.3%), Asp94Gly in gyrA gene (53.9%) and A1400G in rrs gene (61.5%), respectively. Spoligotyping and multilocus sequence typing revealed that 69% belonged to Beijing family, especially modern types. Further typing with 26-loci variable number of tandem repeats suggested the current spread of XDR M. tuberculosis. Our result highlights the need to reinforce the TB policy in Nepal with regard to control and detection strategies.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1472-9792
関連情報	PMID 23146281
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.tube.2012.10.007