A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens

Kashiwazaki, Haruhiko; Matsushita, Takae; Sugita, Junichi; Shigematsu, Akio; Kasashi, Kumiko; Yamazaki, Yutaka; Kanehira, Takashi; Kondo, Takeshi; Endo, Tomoyuki; Tanaka, Junji; Hashino, Satoshi; Nishio, Mitsufumi; Imamura, Masahiro; Kitagawa, Yoshimasa; Inoue, Nobuo

A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens

Kashiwazaki, Haruhiko; Matsushita, Takae; Sugita, Junichi et al.

Supportive Care in Cancer, 2012, 20(5), 933-939

Permalink : https://hdl.handle.net/2115/52721

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アクセス権	open access
URI	https://hdl.handle.net/2115/52721
タイトル	A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens
著者	Kashiwazaki, Haruhiko ; Matsushita, Takae ; Sugita, Junichi ; Shigematsu, Akio ; Kasashi, Kumiko ; Yamazaki, Yutaka ; Kanehira, Takashi ; Kondo, Takeshi ; Endo, Tomoyuki ; Tanaka, Junji ; Hashino, Satoshi ; Nishio, Mitsufumi ; Imamura, Masahiro ; Kitagawa, Yoshimasa ; Inoue, Nobuo
e-Rad_Researcher 10344516 著者名 Kashiwazaki, Haruhiko
著者名 Matsushita, Takae
著者名 Sugita, Junichi
著者名 Shigematsu, Akio
著者名 Kasashi, Kumiko
e-Rad_Researcher 90250464 著者名 Yamazaki, Yutaka
e-Rad_Researcher 90194935 著者名 Kanehira, Takashi
e-Rad_Researcher 70333606 著者名 Kondo, Takeshi
著者名 Endo, Tomoyuki
e-Rad_Researcher 50250452 著者名 Tanaka, Junji
e-Rad_Researcher 60271665 著者名 Hashino, Satoshi
e-Rad_Researcher 10322801 著者名 Nishio, Mitsufumi
e-Rad_Researcher 20160062 著者名 Imamura, Masahiro
e-Rad_Researcher 00224957 著者名 Kitagawa, Yoshimasa
e-Rad_Researcher 20091415 著者名 Inoue, Nobuo
言語	英語
キーワード	Hematopoietic stem cell transplantation
	Oral mucositis
	Reduced-intensity regimens
発行日	2012-05
出版者	Springer Berlin / Heidelberg
収録物名	Supportive Care in Cancer
巻(号)	20(5)
ページ	933-939
抄録	Goals of work: Severe oral mucositis developed in allogeneic hematopoietic stem cell transplantation (HSCT) accompanies intolerable pain and risk for systemic bacteremia infection. Conventional stem cell transplantation (CST) and reduced-intensity regimens for allogeneic HSCT (RIST) may differently affect the occurrence and severity of oral mucositis. Here, we comparatively examined oral mucositis in patients undergoing CST and that in RIST patients to search for measures to alleviate oral mucositis. Patients and methods: We retrospectively analyzed the data of 130 consecutive patients undergoing HSCT (conventional, 60; RIST, 70). Oral mucositis was evaluated according to the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 3.0. We also investigated risk factors for severe oral mucositis in each regimen. Main results: The incidence of oral mucositis was not significantly different between RIST and CST patients. Use of opioid analgesics to control pain due to oral mucositis was significantly less in patients undergoing RIST compared with those receiving CST. The risk factors for severe oral mucositis, determined by univariate and multivariate analyses, were "younger age (<40)" in CST and "longer duration of neutropenia (≥ 14 days)" in RIST. Conclusions: Although the incidences of oral mucositis were almost the same, the need for opioid analgesics and the risk factors for severe oral mucositis differed between CST and RIST patients.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final publication is available at www.springerlink.com
PISSN	0941-4355
関連情報	PMID 21494780
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00520-011-1164-2