What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy

Toramatsu, Chie; Katoh, Norio; Shimizu, Shinichi; Nihongi, Hideaki; Matsuura, Taeko; Takao, Seishin; Miyamoto, Naoki; Suzuki, Ryusuke; Sutherland, Kenneth; Kinoshita, Rumiko; Onimaru, Rikiya; Ishikawa, Masayori; Umegaki, Kikuo; Shirato, Hiroki

What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy

Toramatsu, Chie; Katoh, Norio; Shimizu, Shinichi et al.

Radiation Oncology, 2013, 8, 48

Permalink : https://hdl.handle.net/2115/52762

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アクセス権	open access
URI	https://hdl.handle.net/2115/52762
タイトル	What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy
著者	Toramatsu, Chie ; Katoh, Norio ; Shimizu, Shinichi ; Nihongi, Hideaki ; Matsuura, Taeko ; Takao, Seishin ; Miyamoto, Naoki ; Suzuki, Ryusuke ; Sutherland, Kenneth ; Kinoshita, Rumiko ; Onimaru, Rikiya ; Ishikawa, Masayori ; Umegaki, Kikuo ; Shirato, Hiroki
著者名 Toramatsu, Chie
e-Rad_Researcher 80572495 著者名 Katoh, Norio
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
著者名 Nihongi, Hideaki
e-Rad_Researcher 90590266 著者名 Matsuura, Taeko
e-Rad_Researcher 10614216 著者名 Takao, Seishin
e-Rad_Researcher 00552879 著者名 Miyamoto, Naoki
e-Rad_Researcher 00400052 著者名 Suzuki, Ryusuke
e-Rad_Researcher 30451446 著者名 Sutherland, Kenneth
e-Rad_Researcher 70507582 著者名 Kinoshita, Rumiko
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 80314772 著者名 Ishikawa, Masayori
e-Rad_Researcher 40643193 著者名 Umegaki, Kikuo
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Spot-scanning proton therapy
	Intensity-modulated radiation therapy
	Hepatocellular carcinoma
	Radiation induced liver disease
発行日	2013-03-05
出版者	BioMed Central
収録物名	Radiation Oncology
巻(号)	8
ページ	48
抄録	Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD). Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm(3). Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model. Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT. Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 2.0 Generic
PISSN	1748-717X
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1186/1748-717X-8-48