Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)

Kawaguchi, Kohei; Kaneko, Nobuto; Fukuda, Miki; Nakano, Yusuke; Kimura, Shizuo; Hara, Akihiko; Shimizu, Munetaka

Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)

Kawaguchi, Kohei; Kaneko, Nobuto; Fukuda, Miki et al.

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2013, 165(2), 191-198

Permalink : https://hdl.handle.net/2115/52768

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アクセス権	open access
URI	https://hdl.handle.net/2115/52768
タイトル	Responses of insulin-like growth factor (IGF)-I and two IGF-binding protein-1 subtypes to fasting and re-feeding, and their relationships with individual growth rates in yearling masu salmon (Oncorhynchus masou)
著者	Kawaguchi, Kohei ; Kaneko, Nobuto ; Fukuda, Miki ; Nakano, Yusuke ; Kimura, Shizuo ; Hara, Akihiko ; Shimizu, Munetaka
著者名 Kawaguchi, Kohei
著者名 Kaneko, Nobuto
著者名 Fukuda, Miki
著者名 Nakano, Yusuke
著者名 Kimura, Shizuo
e-Rad_Researcher 40091483 著者名 Hara, Akihiko
e-Rad_Researcher 90431337 著者名 Shimizu, Munetaka
言語	英語
キーワード	Insulin-like growth factor (IGF)-I
	IGF-binding protein
	Growth
	Fasting
	Index
	Salmon
発行日	2013-06
出版者	Elsevier
収録物名	Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
巻(号)	165(2)
ページ	191-198
抄録	Two subtypes of insulin-like growth factor binding protein (IGFBP)-1 are present in salmon blood and they are both up-regulated under catabolic conditions such as stress. The present study examined effects of fasting and re-feeding on IGFBP-1a (28-kDa form) and IGFBP-1b (22-kDa form) both at mRNA and protein levels along with IGF-I and RNA/DNA ratio in yearling masu salmon. Fish were individually tagged and assigned to one of three treatments: Fed, Fasted or Re-fed. Circulating IGF-I levels significantly decreased after fasting for 5 weeks and were positively correlated with individual growth rates. Liver igf-1 mRNA levels were not affected by the treatment. Muscle RNA/DNA ratio did not respond to fasting nor showed correlations with growth rates. Circulating IGFBP-1a and IGFBP-1b increased during fasting and decreased after re-feeding. Both serum levels were inversely correlated with growth rates, while IGFBP-1b had consistent negative relationships with growth rates. Fasting/re-feeding also affected their mRNA levels in the liver. These results suggest that circulating IGF-I and IGFBP-1b could serve as positive and negative indices of growth, respectively, in masu salmon. Different sensitivities of IGBP-1a and IGFBP-1b may be useful to assess a broad range of catabolic conditions when they are combined.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1095-6433
NCID	AA11183804
関連情報	PMID 23474252
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.cbpa.2013.02.029