Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women

Kobayashi, Sumitaka; Sata, Fumihiro; Sasaki, Seiko et al.

Toxicology Letters, 2013, 219(3), 269-278

Permalink : https://hdl.handle.net/2115/52913

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アクセス権
open access
URI
https://hdl.handle.net/2115/52913
タイトル
Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women
著者
Kobayashi, Sumitaka ; Sata, Fumihiro ; Sasaki, Seiko ; Ban, Susumu ; Miyashita, Chihiro ; Okada, Emiko ; Limpar, Mariko ; Yoshioka, Eiji ; Kajiwara, Jumboku ; Todaka, Takashi ; Saijo, Yasuaki ; Kishi, Reiko
e-Rad_Researcher
10733371
著者名
Kobayashi, Sumitaka
著者名
Sata, Fumihiro
e-Rad_Researcher
30448831
著者名
Sasaki, Seiko
e-Rad_Researcher
30399828
著者名
Ban, Susumu
e-Rad_Researcher
70632389
著者名
Miyashita, Chihiro
e-Rad_Researcher
00766537
著者名
Okada, Emiko
著者名
Limpar, Mariko
e-Rad_Researcher
70435957
著者名
Yoshioka, Eiji
著者名
Kajiwara, Jumboku
著者名
Todaka, Takashi
e-Rad_Researcher
70360906
著者名
Saijo, Yasuaki
e-Rad_Researcher
80112449
著者名
Kishi, Reiko
言語
英語
キーワード
Aromatic hydrocarbon receptor
Cytochrome P450
Single-nucleotide polymorphism
Dioxin
Blood
発行日
2013-06-07
出版者
Elsevier
収録物名
Toxicology Letters
巻(号)
219(3)
ページ
269-278
抄録
Dioxins are metabolized by cytochrome P450, family 1 (CYP1) via the aromatic hydrocarbon receptor (AHR). We determined whether different blood dioxin concentrations are associated with polymorphisms in AHR (dbSNP ID: rs2066853), AHR repressor (AHRR; rs2292596), CYP1 subfamily A polypeptide 1 (CYP1A1; rs4646903 and rs1048963), CYP1 subfamily A polypeptide 2 (CYP1A2; rs762551), and CYP1 subfamily B polypeptide 1 (CYP1B1; rs1056836) in pregnant Japanese women. These six polymorphisms were detected in 421 healthy pregnant Japanese women. Differences in dioxin exposure concentrations in maternal blood among the genotypes were investigated. Comparisons among the GG, GA, and AA genotypes of AHR showed a significant difference (genotype model: P = 0.016 for the mono-ortho polychlorinated biphenyl concentrations and toxicity equivalence quantities [TEQs]). Second, we found a significant association with the dominant genotype model ([TT + TC] vs. CC: P = 0.048 for the polychlorinated dibenzo-p-dioxin TEQs; P = 0.035 for polychlorinated dibenzofuran TEQs) of CYP1A1 (rs4646903). No significant differences were found among blood dioxin concentrations and polymorphisms in AHRR, CYP1A1 (rs1048963), CYP1A2, and CYP1B1. Thus, polymorphisms in AHR and CYP1A1 (rs4646903) were associated with maternal dioxin concentrations. However, differences in blood dioxin concentrations were relatively low.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0378-4274
NCID
AA00864457
関連情報
PMID
23528250
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.toxlet.2013.03.013