Nanoscale fluctuations on epithelial cell surfaces investigated by scanning ion conductance microscopy

Mizutani, Yusuke; Choi, Myung-Hoon; Cho, Sang-Joon et al.

Applied Physics Letters, 2013, 102(17), 173703-1-173703-4

Permalink : https://hdl.handle.net/2115/52944

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アクセス権
open access
URI
https://hdl.handle.net/2115/52944
タイトル
Nanoscale fluctuations on epithelial cell surfaces investigated by scanning ion conductance microscopy
著者
Mizutani, Yusuke ; Choi, Myung-Hoon ; Cho, Sang-Joon ; Okajima, Takaharu
著者名
Mizutani, Yusuke
著者名
Choi, Myung-Hoon
著者名
Cho, Sang-Joon
e-Rad_Researcher
70280998
著者名
Okajima, Takaharu
言語
英語
キーワード
biological techniques
biomechanics
biomembrane transport
cellular biophysics
ion microscopes
発行日
2013-04-29
出版者
AIP
収録物名
Applied Physics Letters
巻(号)
102(17)
ページ
173703-1-173703-4
抄録
Nanoscale fluctuations on the apical surfaces of epithelial cells connected to neighboring cells were investigated by scanning ion conductance microscopy. Mapping the ion current as a function of the tip-surface distance revealed that in untreated cells, the apparent fluctuation amplitude increased towards the cell center. We found that the spatial dependence was less correlated with the heterogeneities of cell stiffness but was significantly reduced when actin filaments were disrupted. The results indicate that apical surface fluctuations are highly constrained at the cell-cell interface, in the vertical direction to the surface and by the underlying actin filaments. (C) 2013 AIP Publishing LLC.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
権利情報
Copyright 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Appl. Phys. Lett. 102, 173703 (2013) and may be found at https://dx.doi.org/10.1063/1.4803469
PISSN
0003-6951
EISSN
1077-3118
NCID
AA00543431
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1063/1.4803469