Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Guo, Ying; Li, Minqi; Liu, Zhusheng; Yamada, Tamaki; Sasaki, Muneteru; Hasegawa, Tomoka; Hongo, Hiromi; Tabata, Chihiro; Suzuki, Reiko; Oda, Kimimitsu; Yamamoto, Tsuneyuki; Kawanami, Masamitsu; Amizuka, Norio

Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats

Guo, Ying; Li, Minqi; Liu, Zhusheng et al.

Journal of Electron Microscopy, 2012, 61(5), 309-320

Permalink : https://hdl.handle.net/2115/52954

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アクセス権	open access
URI	https://hdl.handle.net/2115/52954
タイトル	Immunolocalization of sclerostin synthesized by osteocytes in relation to bone remodeling in the interradicular septa of ovariectomized rats
著者	Guo, Ying ; Li, Minqi ; Liu, Zhusheng ; Yamada, Tamaki ; Sasaki, Muneteru ; Hasegawa, Tomoka ; Hongo, Hiromi ; Tabata, Chihiro ; Suzuki, Reiko ; Oda, Kimimitsu ; Yamamoto, Tsuneyuki ; Kawanami, Masamitsu ; Amizuka, Norio
著者名 Guo, Ying
e-Rad_Researcher 60447612 著者名 Li, Minqi
著者名 Liu, Zhusheng
著者名 Yamada, Tamaki
著者名 Sasaki, Muneteru
著者名 Hasegawa, Tomoka
著者名 Hongo, Hiromi
著者名 Tabata, Chihiro
e-Rad_Researcher 90333723 著者名 Suzuki, Reiko
著者名 Oda, Kimimitsu
e-Rad_Researcher 80200822 著者名 Yamamoto, Tsuneyuki
e-Rad_Researcher 10133761 著者名 Kawanami, Masamitsu
e-Rad_Researcher 30242431 著者名 Amizuka, Norio
言語	英語
キーワード	ovariectomy
	osteocyte
	sclerostin
	estrogen receptor α
	alveolar bone
発行日	2012-10
出版者	Oxford University Press
収録物名	Journal of Electron Microscopy
巻(号)	61(5)
ページ	309-320
抄録	This study aimed to elucidate whether estrogen deficiency would affect the synthesis of an osteocyte-derived factor, sclerostin, in the mesial region of alveolar bone. Eight 9-week-old Wistar female rats were ovariectomized (OVX) and the other eight rats were Sham-operated (Sham). After 4 weeks, the interradicular septa of mandibular first molar were embedded in paraffin, and then, were histochemically examined. Sclerostin-positive osteocytes were located in a superficial layer of the mesial region of Sham bone, while the OVX mesial region showed a lesser presence of the sclerostin-reactive osteocytes. There was no significant difference in the distribution of estrogen receptor α and TUNEL-positive cells in either Sham or OVX groups. Meanwhile, the Sham mesial region demonstrated many osteoclasts, but the OVX specimens showed numerous osteoclasts in association with intense immunolabeling of the receptor activator of the nuclear factor kB ligand. Complex meshwork of cement lines was seen consistent with irregularly-distributed osteocytic lacunar-canalicular system in the OVX mesial region, compared with those of the Sham specimens. In conclusion, estrogen deficiency appears to inhibit osteocytes for sclerostin synthesis in the mesial region of the interradicular septum, mediated by accelerated bone remodeling, rather than by directly effecting osteocytes.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Electron Microscopy following peer review. The definitive publisher-authenticated version J Electron Microsc (Tokyo) (2012) 61 (5): 309-320 is available online at: http://jmicro.oxfordjournals.org/content/61/5/309
PISSN	0022-0744
関連情報	PMID 22802488
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1093/jmicro/dfs052