Genetic and Biological Characterization of Tick-Borne Encephalitis Virus Isolated from Wild Rodents in Southern Hokkaido, Japan in 2008

Kentaro, Yoshii; Yamazaki, Shoko; Mottate, Keita; Nagata, Noriyo; Seto, Takahiro; Sanada, Takashiro; Sakai, Mizuki; Kariwa, Hiroaki; Takashima, Ikuo

Genetic and Biological Characterization of Tick-Borne Encephalitis Virus Isolated from Wild Rodents in Southern Hokkaido, Japan in 2008

Kentaro, Yoshii; Yamazaki, Shoko; Mottate, Keita et al.

Vector-Borne And Zoonotic Diseases, 2013, 13(6), 406-414

Permalink : https://hdl.handle.net/2115/53028

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アクセス権	open access
URI	https://hdl.handle.net/2115/53028
タイトル	Genetic and Biological Characterization of Tick-Borne Encephalitis Virus Isolated from Wild Rodents in Southern Hokkaido, Japan in 2008
著者	Kentaro, Yoshii ; Yamazaki, Shoko ; Mottate, Keita ; Nagata, Noriyo ; Seto, Takahiro ; Sanada, Takashiro ; Sakai, Mizuki ; Kariwa, Hiroaki ; Takashima, Ikuo
e-Rad_Researcher 50421988 著者名 Kentaro, Yoshii
著者名 Yamazaki, Shoko
著者名 Mottate, Keita
e-Rad_Researcher 30270648 著者名 Nagata, Noriyo
著者名 Seto, Takahiro
著者名 Sanada, Takashiro
著者名 Sakai, Mizuki
e-Rad_Researcher 70224714 著者名 Kariwa, Hiroaki
e-Rad_Researcher 30002083 著者名 Takashima, Ikuo
言語	英語
キーワード	Tick-borne encephalitis virus
	Oshima 08-As
	Oshima 5-10
	Hokkaido
発行日	2013-06
出版者	Mary Ann Liebert Inc
収録物名	Vector-Borne And Zoonotic Diseases
巻(号)	13(6)
ページ	406-414
抄録	Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis in humans. A recent epizootiological survey indicated that endemic foci of TBEV have been maintained in the southern part of Hokkaido until recently. In this study, we sought to isolate TBEV from wild rodents in the area. One virus, designated Oshima 08-As, was isolated from an Apodemus speciosus captured in Hokuto in 2008. Oshima 08-As was classified as the Far Eastern subtype of TBEV and formed a cluster with the other strains isolated in Hokkaido from 1995 to 1996. Thirty-six nucleotide differences resulted in 12 amino acid changes between Oshima 08-As and Oshima 5-10 isolated in 1995. Oshima 08-As caused high mortality and morbidity in a mouse model compared with Oshima 5-10. Although similar transient viral multiplication in the spleen was observed in the mice infected with Oshima 08-As and Oshima 5-10, greater viral multiplication with an inflammatory response was noted in the brains of mice infected with Oshima 08-As than those infected with Oshima 5-10. These data indicate that a few naturally occurring mutations affect the pathogenicity of the Oshima strains endemic in the southern part of Hokkaido.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	1530-3667
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1089/vbz.2012.1231