Prediction of Response to Treatment by Gene Expression Profiling of Peripheral Blood in Patients with Microscopic Polyangiitis

Ishizu, Akihiro; Tomaru, Utano; Murai, Taichi; Yamamoto, Tomohiro; Atsumi, Tatsuya; Yoshiki, Takashi; Yumura, Wako; Yamagata, Kunihiro; Yamada, Hidehiro; Kumagai, Shunichi; Kurokawa, Manae S.; Suka, Machi; Makino, Hirofumi; Ozaki, Shoichi

Prediction of Response to Treatment by Gene Expression Profiling of Peripheral Blood in Patients with Microscopic Polyangiitis

Ishizu, Akihiro; Tomaru, Utano; Murai, Taichi et al.

PLoS One, 2013, 8(5), e63182

Permalink : https://hdl.handle.net/2115/53034

このアイテムのアクセス数:1,216件（2026-08-14 01:09 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
journal.pone.0063182	pdf	490 KB	945

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/53034
タイトル	Prediction of Response to Treatment by Gene Expression Profiling of Peripheral Blood in Patients with Microscopic Polyangiitis
著者	Ishizu, Akihiro ; Tomaru, Utano ; Murai, Taichi ; Yamamoto, Tomohiro ; Atsumi, Tatsuya ; Yoshiki, Takashi ; Yumura, Wako ; Yamagata, Kunihiro ; Yamada, Hidehiro ; Kumagai, Shunichi ; Kurokawa, Manae S. ; Suka, Machi ; Makino, Hirofumi ; Ozaki, Shoichi
e-Rad_Researcher 60321957 著者名 Ishizu, Akihiro
e-Rad_Researcher 20360901 著者名 Tomaru, Utano
著者名 Murai, Taichi
著者名 Yamamoto, Tomohiro
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
e-Rad_Researcher 60220612 著者名 Yoshiki, Takashi
著者名 Yumura, Wako
e-Rad_Researcher 90312850 著者名 Yamagata, Kunihiro
e-Rad_Researcher 00174730 著者名 Yamada, Hidehiro
e-Rad_Researcher 00153346 著者名 Kumagai, Shunichi
e-Rad_Researcher 90301598 著者名 Kurokawa, Manae S.
e-Rad_Researcher 30339858 著者名 Suka, Machi
e-Rad_Researcher 50165685 著者名 Makino, Hirofumi
e-Rad_Researcher 00231233 著者名 Ozaki, Shoichi
言語	英語
発行日	2013-05-17
出版者	Public Library of Science
収録物名	PLoS One
巻(号)	8(5)
ページ	e63182
抄録	The JMAAV study was an open-labeled prospective clinical trial, which proposed severity-based treatment protocols for patients with microscopic polyangiitis (MPA). The results suggest that the proposed protocols are useful (remission rate: 89.4%), but are also indicative of relapse or patient demise regardless of the treatment (recurrence rate: 19.0%; mortality rate: 10.6%). The aim of this study is to develop the method to predict response to the treatment in patients with MPA. In the present study, transcriptome analysis was performed using peripheral blood from patients enrolled in the JMAAV study before and 1-week after the beginning of treatment. The gene expression profile before treatment was not directly related to the response to the treatment. However, when the samples from 9 patients with good response (persistent remission for 18 months) were examined, the expression of 88 genes was significantly altered by the treatment. Thirty statistically reliable genes were selected, and then the alteration of expression by the treatment was examined among 22 patients, including 17 with good response, which was defined as persistent remission for 18 months and 5 with poor response, which was defined as relapse after remission or no remission. Discrimination analysis between the alteration of expression of the 30 genes by the treatment and the response identified a combination of 16 genes as the most valuable gene set to predict the response to the treatment. This preliminary study identified IRF7, IFIT1, IFIT5, OASL, CLC, GBP-1, PSMB9, HERC5, CCR1, CD36, MS4A4A, BIRC4BP, PLSCR1, DEFA1/DEFA3, DEFA4, and COL9A2 as the important genes that can predict the response to the treatment in patients with MPA at an early point during the therapy.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
PISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0063182