Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome

Yokota, Takashi; Kinugawa, Shintaro; Yamato, Mayumi; Hirabayashi, Kagami; Suga, Tadashi; Takada, Shingo; Harada, Kuniaki; Morita, Noriteru; Oyama-Manabe, Noriko; Kikuchi, Yasuka; Okita, Koichi; Tsutsui, Hiroyuki

Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome

Yokota, Takashi; Kinugawa, Shintaro; Yamato, Mayumi et al.

Diabetes Care, 2013, 36(5), 1341-1346

Permalink : https://hdl.handle.net/2115/53043

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アクセス権	open access
URI	https://hdl.handle.net/2115/53043
タイトル	Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic Syndrome
著者	Yokota, Takashi ; Kinugawa, Shintaro ; Yamato, Mayumi ; Hirabayashi, Kagami ; Suga, Tadashi ; Takada, Shingo ; Harada, Kuniaki ; Morita, Noriteru ; Oyama-Manabe, Noriko ; Kikuchi, Yasuka ; Okita, Koichi ; Tsutsui, Hiroyuki
e-Rad_Researcher 90374321 著者名 Yokota, Takashi
e-Rad_Researcher 60399871 著者名 Kinugawa, Shintaro
e-Rad_Researcher 30380695 著者名 Yamato, Mayumi
著者名 Hirabayashi, Kagami
e-Rad_Researcher 30708673 著者名 Suga, Tadashi
e-Rad_Researcher 60722329 著者名 Takada, Shingo
e-Rad_Researcher 50423760 著者名 Harada, Kuniaki
e-Rad_Researcher 10382540 著者名 Morita, Noriteru
e-Rad_Researcher 70463742 著者名 Oyama-Manabe, Noriko
e-Rad_Researcher 80783539 著者名 Kikuchi, Yasuka
e-Rad_Researcher 80382539 著者名 Okita, Koichi
e-Rad_Researcher 70264017 著者名 Tsutsui, Hiroyuki
言語	英語
発行日	2013-05
出版者	Amer Diabetes Assoc
収録物名	Diabetes Care
巻(号)	36(5)
ページ	1341-1346
抄録	OBJECTIVE-Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS). RESEARCH DESIGN AND METHODS-The incremental exercise testing with cycle ergometer was performed in 14 male patients with MetS and 13 age-, sex-, and activity-matched healthy subjects. Systemic lipid peroxidation was assessed by serum thiobarbituric acid reactive substances (TBARS), and systemic antioxidant defense capacity was assessed by serum total thiols and enzymatic activity of superoxide dismutase (SOD). To assess skeletal muscle energy metabolism, we measured high-energy phosphates in the calf muscle during plantar flexion exercise and intramyocellular lipid (IMCL) in the resting leg muscle, using P-31- and (1)proton-magnetic resonance spectroscopy, respectively. RESULTS-Serum TBARS were elevated (12.4 +/- 7.1 vs. 3.7 +/- 1.1 mu mol/L; P < 0.01), and serum total thiols and SOD activity were decreased (290.8 +/- 51.2 vs. 398.7 +/- 105.2 mu mol/L, P < 0.01; and 22.2 +/- 8.4 vs. 31.5 +/- 8.5 units/L, P < 0.05, respectively) in patients with MetS compared with healthy subjects. Peak VO2 and anaerobic threshold normalized to body weight were significantly lower in MetS patients by 25 and 31%, respectively, and inversely correlated with serum TBARS (r = -0.49 and r = -0.50, respectively). Moreover, muscle phosphocreatine loss during exercise was 1.4-fold greater in patients with MetS (P < 0.05), and IMCL content was 2.9-fold higher in patients with MetS (P < 0.01), indicating impaired skeletal muscle energy metabolism, and these indices positively correlated with serum TBARS (r = 0.45 and r = 0.63, respectively). CONCLUSIONS-Systemic oxidative stress was associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with MetS.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0149-5992
EISSN	1935-5548
関連情報	PMID 23393211
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.2337/dc12-1161