Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

Tha, Khin K.; Terae, Satoshi; Nakagawa, Shin; Inoue, Takeshi; Kitagawa, Nobuki; Kako, Yuki; Nakato, Yasuya; Popy, Kawser Akter; Fujima, Noriyuki; Zaitsu, Yuri; Yoshida, Daisuke; Ito, Yoichi M.; Miyamoto, Tamaki; Koyama, Tsukasa; Shirato, Hiroki

Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging

Tha, Khin K.; Terae, Satoshi; Nakagawa, Shin et al.

Psychiatry Research : Neuroimaging, 2013, 212(3), 208-215

Permalink : https://hdl.handle.net/2115/53150

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アクセス権	open access
URI	https://hdl.handle.net/2115/53150
タイトル	Impaired integrity of the brain parenchyma in non-geriatric patients with major depressive disorder revealed by diffusion tensor imaging
著者	Tha, Khin K. ; Terae, Satoshi ; Nakagawa, Shin ; Inoue, Takeshi ; Kitagawa, Nobuki ; Kako, Yuki ; Nakato, Yasuya ; Popy, Kawser Akter ; Fujima, Noriyuki ; Zaitsu, Yuri ; Yoshida, Daisuke ; Ito, Yoichi M. ; Miyamoto, Tamaki ; Koyama, Tsukasa ; Shirato, Hiroki
e-Rad_Researcher 20451445 著者名 Tha, Khin K.
e-Rad_Researcher 40240634 著者名 Terae, Satoshi
e-Rad_Researcher 60360905 著者名 Nakagawa, Shin
e-Rad_Researcher 70250438 著者名 Inoue, Takeshi
e-Rad_Researcher 80312362 著者名 Kitagawa, Nobuki
e-Rad_Researcher 70374444 著者名 Kako, Yuki
著者名 Nakato, Yasuya
著者名 Popy, Kawser Akter
著者名 Fujima, Noriyuki
著者名 Zaitsu, Yuri
著者名 Yoshida, Daisuke
著者名 Ito, Yoichi M.
e-Rad_Researcher 20271679 著者名 Miyamoto, Tamaki
e-Rad_Researcher 10113557 著者名 Koyama, Tsukasa
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	Fractional anisotropy
	Mean diffusivity
	Voxel-based analysis
	Histogram
発行日	2013-06-30
出版者	Elsevier Ireland Ltd
収録物名	Psychiatry Research : Neuroimaging
巻(号)	212(3)
ページ	208-215
抄録	Diffusion tensor imaging (DTI) is considered to be able to non-invasively quantify white matter integrity. This study aimed to use DTI to evaluate white matter integrity in non-geriatric patients with major depressive disorder (MDD) who were free of antidepressant medication. DTI was performed on 19 non-geriatric patients with MDD, free of antidepressant medication, and 19 age-matched healthy subjects. Voxel-based and histogram analyses were used to compare fractional anisotropy (FA) and mean diffusivity (MD) values between the two groups, using two-sample t tests. The abnormal DTI indices, if any, were tested for correlation with disease duration and severity, using Pearson product-moment correlation analysis. Voxel-based analysis showed clusters with FA decrease at the bilateral frontal white matter, anterior limbs of internal capsule, cerebellum, left putamen and right thalamus of the patients. Histogram analysis revealed lower peak position of FA histograms in the patients. FA values of the abnormal clusters and peak positions of FA histograms of the patients exhibited moderate correlation with disease duration and severity. These results suggest the implication of frontal-subcortical circuits and cerebellum in MDD, and the potential utility of FA in evaluation of brain parenchymal integrity. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0925-4927
NCID	AA0036432X
関連情報	PMID 23149032
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.pscychresns.2012.07.004