Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull

Kashiwazaki, Haruhiko; Harada, Naoki; Akazawa, Toshiyuki et al.

Journal of hard tissue biology, 2013, 22(3), 337-341

Permalink : https://hdl.handle.net/2115/53343

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アクセス権
open access
URI
https://hdl.handle.net/2115/53343
タイトル
Bone Augmentation Using Novel Unidirectional Porous Hydroxyapatite with Bone Morphogenetic Protein-2 on Rat Skull
著者
Kashiwazaki, Haruhiko ; Harada, Naoki ; Akazawa, Toshiyuki ; Kabir, Md. Arafat ; Minamida, Yasuhito ; Murata, Masaru
e-Rad_Researcher
10344516
著者名
Kashiwazaki, Haruhiko
著者名
Harada, Naoki
e-Rad_Researcher
80469692
著者名
Akazawa, Toshiyuki
著者名
Kabir, Md. Arafat
著者名
Minamida, Yasuhito
e-Rad_Researcher
00260662
著者名
Murata, Masaru
言語
英語
キーワード
Unidirectional porous hydroxyapatite (UDPHAp)
Onlay graft
Bone augmentation
Recombinant human bone morphogenetic protein-2 (rhBMP-2)
発行日
2013-07
出版者
Journal hard tissue biology
収録物名
Journal of hard tissue biology
巻(号)
22(3)
ページ
337-341
抄録
Unidirectional porous hydroxyapatite (UDPHAp) is a material whose microstructure consists of cross-sectional oval pores with a pore diameter in the range of 100-300 mu m that penetrate through the material. UDPHAp has proven suitable for osteogenesis and angiogenesis. The present study was designed to evaluate the osteogenic effect of a newly developed UDPHAp as a carrier of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a rat onlay graft model. UDPHAp was implanted beneath the calvarial periosteum of rats to simulate alveolar bone augmentation in a clinical condition. At 2 weeks after implantation, UDPHAp with rhBMP-2 resulted in active bone formation, and the augmented bone was connected directly with the original bone, whereas commercialized porous hydroxyapatite (PHAp) with rhBMP-2 showed little bone formation. These results suggest that UDPHAp in this model is suitable for onlay graft and is an effective biomaterial for the rhBMP-2 delivery system.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
1341-7649
NCID
AA11074332
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.2485/jhtb.22.337