Methyl Caffeate as an α-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds

TAKAHASHI, Keisuke; YOSHIOKA, Yasuyuki; KATO, Eisuke et al.

Bioscience, Biotechnology, and Biochemistry, 2010, 74(4), 741-745

Permalink : https://hdl.handle.net/2115/53430

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アクセス権
open access
URI
https://hdl.handle.net/2115/53430
タイトル
Methyl Caffeate as an α-Glucosidase Inhibitor from Solanum torvum Fruits and the Activity of Related Compounds
著者
TAKAHASHI, Keisuke ; YOSHIOKA, Yasuyuki ; KATO, Eisuke ; KATSUKI, Shigeki ; IIDA, Osamu ; HOSOKAWA, Keizo ; KAWABATA, Jun
著者名
TAKAHASHI, Keisuke
著者名
YOSHIOKA, Yasuyuki
e-Rad_Researcher
40466446
著者名
KATO, Eisuke
著者名
KATSUKI, Shigeki
著者名
IIDA, Osamu
著者名
HOSOKAWA, Keizo
e-Rad_Researcher
60142197
著者名
KAWABATA, Jun
言語
英語
キーワード
Solanum torvum
α-glucosidase inhibitor
methyl caffeate
Tanegashima
発行日
2010-04
出版者
日本農芸化学会
Japan Society for Bioscience, Biotechnology, and Agrochemistry
収録物名
Bioscience, Biotechnology, and Biochemistry
巻(号)
74(4)
ページ
741-745
抄録
In screening experiments for rat intestinal α-glucosidase (sucrase and maltase) inhibitors in 325 plants cultivated in Japan’s southern island, of Tanegashima, marked inhibition against both sucrase and maltase was found in the extract of the fruit of Solanum torvum. Enzyme-assay guided fractionation of the extract led to the isolation of methyl caffeate (1) as a rat intestinal sucrase and maltase inhibitor. We examined 13 caffeoyl derivatives for sucrase- and maltase-inhibitory activities. The results showed that methyl caffeate (1) had a most favorable structure for both sucrase and maltase inhibition, except for a higher activity of methyl 3,4,5-trihydroxycinnamate (14) against sucrase. Its moderate inhibitory action against α-glucosidase provides a prospect for antidiabetic usage of S. torvum fruit.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0916-8451
EISSN
1347-6947
関連情報
PMID
20378981
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1271/bbb.90789