Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease

Eriguchi, Yoshihiro; Uryu, Hidetaka; Nakamura, Kiminori; Shimoji, Sonoko; Takashima, Shuichiro; Iwasaki, Hiromi; Miyamoto, Toshihiro; Shimono, Nobuyuki; Hashimoto, Daigo; Akashi, Koichi; Ayabe, Tokiyoshi; Teshima, Takanori

Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease

Eriguchi, Yoshihiro; Uryu, Hidetaka; Nakamura, Kiminori et al.

Biology of blood and marrow transplantation, 2013, 19(10), 1525-1529

Permalink : https://hdl.handle.net/2115/53606

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アクセス権	open access
URI	https://hdl.handle.net/2115/53606
タイトル	Reciprocal Expression of Enteric Antimicrobial Proteins in Intestinal Graft-Versus-Host Disease
著者	Eriguchi, Yoshihiro ; Uryu, Hidetaka ; Nakamura, Kiminori ; Shimoji, Sonoko ; Takashima, Shuichiro ; Iwasaki, Hiromi ; Miyamoto, Toshihiro ; Shimono, Nobuyuki ; Hashimoto, Daigo ; Akashi, Koichi ; Ayabe, Tokiyoshi ; Teshima, Takanori
著者名 Eriguchi, Yoshihiro
著者名 Uryu, Hidetaka
著者名 Nakamura, Kiminori
著者名 Shimoji, Sonoko
著者名 Takashima, Shuichiro
著者名 Iwasaki, Hiromi
著者名 Miyamoto, Toshihiro
著者名 Shimono, Nobuyuki
著者名 Hashimoto, Daigo
著者名 Akashi, Koichi
著者名 Ayabe, Tokiyoshi
e-Rad_Researcher 40284096 著者名 Teshima, Takanori
言語	英語
キーワード	Hematopoietic stem cell transplantation
	Graft-versus-host disease
	Regenerating islet-derived III
	Defensins
	Toll-like receptors
発行日	2013-10
出版者	Elsevier science inc
収録物名	Biology of blood and marrow transplantation
巻(号)	19(10)
ページ	1525-1529
抄録	We recently demonstrated that expression of alpha-defensins, the major antimicrobial peptides produced by Paneth cells, was severely suppressed in mice with graft-versus-host disease (GVHD). In this study, we found that antibacterial lectin, regenerating islet-derived III gamma (RegIII gamma) was upregulated in villous enterocytes, thus demonstrating the reciprocal control of enteric antimicrobial proteins in GVHD. Upregulation of RegIII gamma was mediated by a mechanism independent upon radiation-induced intestinal tract damage. MyD88-mediated signaling in intestinal epithelium was required for RegIII gamma upregulation in GVHD and antibiotic therapy downregulated RegIII gamma expression. These results suggest that MyD88-mediated sensing of the intestinal microbes disregulated in GVHD induces RegIII gamma upregulation in GVHD and argue a role for RegIII gamma in the pathogenesis of GVHD. (C) 2013 American Society for Blood and Marrow Transplantation.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1083-8791
NCID	AA11361618
関連情報	PMID 23927965
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.bbmt.2013.07.027