Transcriptional Activation of the Cholecystokinin Gene by DJ-1 through Interaction of DJ-1 with RREB1 and the Effect of DJ-1 on the Cholecystokinin Level in Mice

Yamane, Takuya; Suzui, Sayaka; Kitaura, Hirotake; Takahashi-Niki, Kazuko; Iguchi-Ariga, Sanae M. M.; Ariga, Hiroyoshi

Transcriptional Activation of the Cholecystokinin Gene by DJ-1 through Interaction of DJ-1 with RREB1 and the Effect of DJ-1 on the Cholecystokinin Level in Mice

Yamane, Takuya; Suzui, Sayaka; Kitaura, Hirotake et al.

PLoS ONE, 2013, 8(11), e78374

Permalink : https://hdl.handle.net/2115/53695

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アクセス権	open access
URI	https://hdl.handle.net/2115/53695
タイトル	Transcriptional Activation of the Cholecystokinin Gene by DJ-1 through Interaction of DJ-1 with RREB1 and the Effect of DJ-1 on the Cholecystokinin Level in Mice
著者	Yamane, Takuya ; Suzui, Sayaka ; Kitaura, Hirotake ; Takahashi-Niki, Kazuko ; Iguchi-Ariga, Sanae M. M. ; Ariga, Hiroyoshi
著者名 Yamane, Takuya
著者名 Suzui, Sayaka
e-Rad_Researcher 10281817 著者名 Kitaura, Hirotake
e-Rad_Researcher 50447645 著者名 Takahashi-Niki, Kazuko
e-Rad_Researcher 90184283 著者名 Iguchi-Ariga, Sanae M. M.
e-Rad_Researcher 20143505 著者名 Ariga, Hiroyoshi
言語	英語
発行日	2013-11-05
出版者	PLOS
収録物名	PLoS ONE
巻(号)	8(11)
ページ	e78374
抄録	DJ-1 is an oncogene and also causative gene for familial Parkinson’s disease. DJ-1 has multiple functions, including transcriptional regulation. DJ-1 acts as a coactivator that binds to various transcription factors, resulting in stimulation or repression of the expression of their target genes. In this study, we found that the cholecystokinin (CCK) gene is a transcriptional target gene for DJ-1. CCK is a peptide hormone and plays roles in contraction of the gallbladder and in promotion of secretion of pancreatic fluid. CCK is co-localized with dopamine in the substantia nigra to regulate release of dopamine. Reduced expression of CCK mRNA was observed in DJ-1-knockdown cells. The Ras-responsive element (RRE) and Sp1 site were essential for promoter activity, and DJ-1 stimulated promoter activity by binding to RRE-binding protein 1 (RREBP1). The complex of DJ-1 with RREB1 but not with Sp1 bound to the RRE. Furthermore, the reduced CCK level in the serum from DJ-1-knockout mice compared to that from wild-type mice was observed. This is the first report showing that DJ-1 participates in peptide hormone synthesis.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
EISSN	1932-6203
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1371/journal.pone.0078374