Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.

Itoh, Yuka; Hayashi, Hidetoshi; Xu, Jian; Takii, Takemasa; Miyazawa, Keiji; Ariga, Hiroyoshi; Akahoshi, Tohru; Waguri-Nagaya, Yuko; Otsuka, Takanobu; Okamoto, Takashi; Onozaki, Kikuo

Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.

Itoh, Yuka; Hayashi, Hidetoshi; Xu, Jian et al.

Biological & pharmaceutical bulletin, 2007, 30(6), 1140-1143

Permalink : https://hdl.handle.net/2115/53729

このアイテムのアクセス数:954件（2026-10-11 23:29 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
176_Ariga_Biol_Pharm_Bull	pdf	256 KB	574

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/53729
タイトル	Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.
著者	Itoh, Yuka ; Hayashi, Hidetoshi ; Xu, Jian ; Takii, Takemasa ; Miyazawa, Keiji ; Ariga, Hiroyoshi ; Akahoshi, Tohru ; Waguri-Nagaya, Yuko ; Otsuka, Takanobu ; Okamoto, Takashi ; Onozaki, Kikuo
e-Rad_Researcher 40454326 著者名 Itoh, Yuka
e-Rad_Researcher 80198853 著者名 Hayashi, Hidetoshi
著者名 Xu, Jian
e-Rad_Researcher 80244573 著者名 Takii, Takemasa
著者名 Miyazawa, Keiji
e-Rad_Researcher 20143505 著者名 Ariga, Hiroyoshi
e-Rad_Researcher 70159325 著者名 Akahoshi, Tohru
著者名 Waguri-Nagaya, Yuko
e-Rad_Researcher 10185316 著者名 Otsuka, Takanobu
e-Rad_Researcher 40146600 著者名 Okamoto, Takashi
e-Rad_Researcher 20101313 著者名 Onozaki, Kikuo
言語	英語
キーワード	rheumatoid arthritis
	synoviocytes
	interleukin-1 (IL-1)
	tumor necrosis factor (TNF) α
	androgen
	androgen receptor
発行日	2007-06
出版者	The Pharmaceutical Society of Japan
収録物名	Biological & pharmaceutical bulletin
巻(号)	30(6)
ページ	1140-1143
抄録	Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects multiple synovial joints. Proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor (TNF)alpha play important roles as principle inflammatory and destructive components of the disease. RA is known to be associated with significant gender differences in its prevalence and clinical features. We found that a potent androgen, 5alpha-dihydrotestosterone (DHT) inhibits IL-1alpha mRNA expression induced by TNFalpha and the DHT effect was inhibited by an androgen receptor antagonist, hydroxyflutamide (OHF). DHT inhibited the NF-kappaB activation induced by TNFalpha in a manner dependent on the androgen receptor (AR). These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-6158
関連情報	PMID 17541168
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/bpb.30.1140