Comparison of the compositions of phospholipid-associated fatty acids in wild-type and extracellular matrix tenascin-X-deficient mice.

Matsumoto, Ken-Ichi; Sato, Takashige; Oka, Seiko; Inokuchi, Jin-Ichi; Ariga, Hiroyoshi

Comparison of the compositions of phospholipid-associated fatty acids in wild-type and extracellular matrix tenascin-X-deficient mice.

Matsumoto, Ken-Ichi; Sato, Takashige; Oka, Seiko et al.

Biological & pharmaceutical bulletin, 2004, 27(9), 1447-1450

Permalink : https://hdl.handle.net/2115/53740

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アクセス権	open access
URI	https://hdl.handle.net/2115/53740
タイトル	Comparison of the compositions of phospholipid-associated fatty acids in wild-type and extracellular matrix tenascin-X-deficient mice.
著者	Matsumoto, Ken-Ichi ; Sato, Takashige ; Oka, Seiko ; Inokuchi, Jin-Ichi ; Ariga, Hiroyoshi
著者名 Matsumoto, Ken-Ichi
著者名 Sato, Takashige
著者名 Oka, Seiko
著者名 Inokuchi, Jin-Ichi
e-Rad_Researcher 20143505 著者名 Ariga, Hiroyoshi
言語	英語
キーワード	tenascin-X
	phospholipid
	triglyceride
	fatty acid
	phosphatidylcholine
	phosphatidylethanolamine
発行日	2004-09
出版者	The Pharmaceutical Society of Japan
収録物名	Biological & pharmaceutical bulletin
巻(号)	27(9)
ページ	1447-1450
抄録	Tenascin-X (TNX) is a member of the tenascin family of glycoproteins of the extracellular matrix. We previously showed that TNX regulates the synthesis of triglyceride and the composition of triglyceride-associated fatty acids. The aim of the present study was to determine whether TNX controls the synthesis of phospholipids and the composition of phospholipid-associated fatty acids by using TNX-deficient (TNX-/-) mice and TNX-overexpressing fibroblast cell lines. Thin-layer chromatography of total lipids of the skin and sciatic nerves from wild-type and TNX-/- mice revealed that the amounts of major phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE), in wild-type and TNX-/- mice are not different. Gas chromatography-mass spectrometry showed that the major fatty acid compositions of PC and PE in wild-type and TNX-/- mice are almost the same. Fibroblast cells stably overexpressing TNX also showed almost the same amounts of PC and PE and almost the same fatty acid compositions of PC and PE as those in mock-transfected cells. These results suggest that TNX regulates the amount of triglyceride and the composition of triglyceride-associated fatty acids but not the amount and species of phospholipids or the composition of phospholipid-associated fatty acids.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0918-6158
関連情報	PMID 15340236
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1248/bpb.27.1447