Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.

Ikuta, Tomoki; Ariga, Hiroyoshi; Matsumoto, Ken-ichi

Biological & pharmaceutical bulletin, 2001, 24(11), 1320-1323

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アクセス権
open access
URI
https://hdl.handle.net/2115/53745
タイトル
Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.
著者
Ikuta, Tomoki ; Ariga, Hiroyoshi ; Matsumoto, Ken-ichi
著者名
Ikuta, Tomoki
e-Rad_Researcher
20143505
著者名
Ariga, Hiroyoshi
著者名
Matsumoto, Ken-ichi
言語
英語
キーワード
tenascin-X
vascular endothelial growth factor A
extracellular matrix
発行日
2001-11
出版者
The Pharmaceutical Society of Japan
収録物名
Biological & pharmaceutical bulletin
巻(号)
24(11)
ページ
1320-1323
抄録
Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo.
資源タイプ
学術雑誌論文
出版タイプ
Version of Record
PISSN
0918-6158
関連情報
PMID
11725972
関連情報 (isIdenticalTo)
出版社版DOI
https://doi.org/10.1248/bpb.24.1320