Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome

Fujieda, Yuichiro; Atsumi, Tatsuya; Amengual, Olga; Odani, Toshio; Otomo, Kotaro; Kato, Masaru; Oku, Kenji; Kon, Yujiro; Horita, Tetsuya; Yasuda, Shinsuke; Koike, Takao

Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome

Fujieda, Yuichiro; Atsumi, Tatsuya; Amengual, Olga et al.

Lupus, 2012, 21(14), 1506-1514

Permalink : https://hdl.handle.net/2115/54013

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アクセス権	open access
URI	https://hdl.handle.net/2115/54013
タイトル	Predominant prevalence of arterial thrombosis in Japanese patients with antiphospholipid syndrome
著者	Fujieda, Yuichiro ; Atsumi, Tatsuya ; Amengual, Olga ; Odani, Toshio ; Otomo, Kotaro ; Kato, Masaru ; Oku, Kenji ; Kon, Yujiro ; Horita, Tetsuya ; Yasuda, Shinsuke ; Koike, Takao
著者名 Fujieda, Yuichiro
e-Rad_Researcher 20301905 著者名 Atsumi, Tatsuya
著者名 Amengual, Olga
著者名 Odani, Toshio
著者名 Otomo, Kotaro
著者名 Kato, Masaru
著者名 Oku, Kenji
著者名 Kon, Yujiro
著者名 Horita, Tetsuya
e-Rad_Researcher 00374231 著者名 Yasuda, Shinsuke
e-Rad_Researcher 80146795 著者名 Koike, Takao
言語	英語
キーワード	Anticardiolipin antibody
	antiphospholipid antibodies
	antiprothrombin antibody
	arterial thrombosis
	lupus anticoagulant
	obstetric complications
	phosphatidylserine dependent
	venous thrombosis
発行日	2012-12
出版者	SAGE Publications
収録物名	Lupus
巻(号)	21(14)
ページ	1506-1514
抄録	Objective: To study the clinical and immunological manifestations of the antiphospholipid syndrome (APS) in Japanese population by a single center registration. Methods: In this retrospective cohort study, 141 consecutive patients with APS, fulfilling the Sydney revised Sapporo criteria for definite APS, who visited to our Autoimmune Clinic from 1988 to 2010 were recruited and followed up. All the patients were interviewed and underwent a general physical examination by qualified rheumatologists on the day of blood sampling. Results: The population comprised 119 woman and 22 men with a mean age at diagnosis of 44 years (range 11-83 years). Seventy patients (49.6%) had primary APS, and 71 (50.4%) had systemic lupus erythematosus. The prevalence of thrombosis was 85.8%, arterial thrombosis was found in 93 patients (66.0%) and venous thrombosis in 46 (32.6%). The most common thrombosis was cerebral infarction [86/141 (61.0%)] followed by deep vein thrombosis [33/141 (23.4%)]. Among 70 pregnant women, 45 (64.3%) had obstetric complications. Lupus anticoagulant was detected in 116 patients (82.3%), anticardiolipin antibodies in 83 (58.9%), anti-β2Glycoprotein I antibodies in 73 (51.8%) and phosphatidylserine-dependent antiprothrombin antibodies in 98 (69.5%). Conclusion: High prevalence of arterial thrombosis was noted in Japanese patients with APS. The profile of heterogeneous and complex clinical manifestations in was substantiated in Japanese patients with APS.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
権利情報	The final, definitive version of this paper has been published in Lupus, 21(14), Dec. 2012 by SAGE Publications Ltd, All rights reserved. © 2012 SAGE Publications
PISSN	0961-2033
関連情報	PMID 22936124
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1177/0961203312458469