Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus

Yoshii, Kentaro; Moritoh, Kanako; Nagata, Noriyo; Yokozawa, Kana; Sakai, Mizuki; Sasaki, Nobuya; Kariwa, Hiroaki; Agui, Takashi; Takashima, Ikuo

Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus

Yoshii, Kentaro; Moritoh, Kanako; Nagata, Noriyo et al.

Archives of Virology, 2013, 158(5), 1039-1046

Permalink : https://hdl.handle.net/2115/54030

このアイテムのアクセス数:1,147件（2026-10-07 09:08 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
Oas ic paper for Arch virol revised2	pdf	1.09 MB	1,111

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/54030
タイトル	Susceptibility to flavivirus-specific antiviral response of Oas1b affects the neurovirulence of the Far-Eastern subtype of tick-borne encephalitis virus
著者	Yoshii, Kentaro ; Moritoh, Kanako ; Nagata, Noriyo ; Yokozawa, Kana ; Sakai, Mizuki ; Sasaki, Nobuya ; Kariwa, Hiroaki ; Agui, Takashi ; Takashima, Ikuo
e-Rad_Researcher 50421988 著者名 Yoshii, Kentaro
著者名 Moritoh, Kanako
e-Rad_Researcher 30270648 著者名 Nagata, Noriyo
著者名 Yokozawa, Kana
著者名 Sakai, Mizuki
e-Rad_Researcher 20302614 著者名 Sasaki, Nobuya
e-Rad_Researcher 70224714 著者名 Kariwa, Hiroaki
e-Rad_Researcher 00212457 著者名 Agui, Takashi
e-Rad_Researcher 30002083 著者名 Takashima, Ikuo
言語	英語
発行日	2013-05
出版者	Springer
収録物名	Archives of Virology
巻(号)	158(5)
ページ	1039-1046
抄録	Tick-borne encephalitis virus (TBEV) is a zoonotic agent that causes fatal encephalitis in humans. 2'-5'-oligoadenylate synthetase 1b (Oas1b) has been identified as a flavivirus resistance gene, but most inbred laboratory mice do not possess a functional Oas1b gene. In this study, a congenic strain carrying a functional Oas1b gene, B6.MSM-Oas, was used to evaluate the pathogenicity of Far-Eastern TBEV. Although intracerebral infection of B6.MSM-Oas mice by Oshima 5-10 resulted in limited signs of illness, infection by Sofjin-HO resulted in death with severe neurologic signs. While Oshima 5-10 was cleared from the brain, Sofjin-HO was not cleared despite a similar level of expression of the intact Oas1b gene. Necrotic neurons with viral antigens and inflammatory reactions were observed in the brain infected with Sofjin-HO. These data indicate that the different susceptibility to the antiviral activity of Oas1b resulted in a difference in neurovirulence in the two TBEV strains.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0304-8608
関連情報	PMID 23266832
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1007/s00705-012-1579-1