c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.

Iguchi-Ariga, Sanae M. M.; Itani, Teru; Yamaguchi, Masamitsu; Ariga, Hiroyoshi

c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.

Iguchi-Ariga, Sanae M. M.; Itani, Teru; Yamaguchi, Masamitsu et al.

Nucleic acids research, 1987, 15(12), 4889-4899

Permalink : https://hdl.handle.net/2115/54049

このアイテムのアクセス数:845件（2026-10-07 17:17 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数	説明
27_Ariga_1987_Nucleic_Acids_Res	pdf	1.12 MB	788

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/54049
タイトル	c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
著者	Iguchi-Ariga, Sanae M. M. ; Itani, Teru ; Yamaguchi, Masamitsu ; Ariga, Hiroyoshi
e-Rad_Researcher 90184283 著者名 Iguchi-Ariga, Sanae M. M.
著者名 Itani, Teru
著者名 Yamaguchi, Masamitsu
e-Rad_Researcher 20143505 著者名 Ariga, Hiroyoshi
言語	英語
発行日	1987-06-25
出版者	Oxford University Press
収録物名	Nucleic acids research
巻(号)	15(12)
ページ	4889-4899
抄録	Replicating activity of SV40 origin-containing plasmid was tested in human cells as well as in monkey CosI cells. All the plasmids possessing SV40 ori sequences could replicate, even in the absence of SV40 T antigen, in human HL-60 and Raji cells which are expressing c-myc gene at high level. The copy numbers of the replicated plasmids in these human cells were 1/100 as high as in monkey CosI cells which express SV40 T antigen constitutively. Exactly the same plasmids as the transfected original ones were recovered from the Hirt supernatant of the transfected HL-60 cells. Furthermore, replication of the SV40 ori-containing plasmids in HL-60 cells was inhibited by anti-c-myc antibody co-transfected into the cells. These results indicate that the c-myc protein can be substituted for SV40 T antigen in SV40 DNA replication.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0305-1048
関連情報	PMID 3037484
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1093/nar/15.12.4889