Aspartame-induced apoptosis in PC12 cells

Horio, Yukari; Sun, Yongkun; Liu, Chuang; Saito, Takeshi; Kurasaki, Masaaki

Aspartame-induced apoptosis in PC12 cells

Horio, Yukari; Sun, Yongkun; Liu, Chuang et al.

Environmental Toxicology and Pharmacology, 2014, 37(1), 158-165

Permalink : https://hdl.handle.net/2115/54098

このアイテムのアクセス数:1,692件（2026-08-11 21:40 集計）

閲覧可能ファイル

ファイル	フォーマット	サイズ	閲覧回数
HorioETAP-R1	pdf	130 KB	1,865
fig1	jpg	262 KB	870
Fig. 2	pdf	41.6 KB	1,086
fig3	jpg	155 KB	761
fig4	jpg	270 KB	943
fig5	jpg	288 KB	1,950

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

アクセス権	open access
URI	https://hdl.handle.net/2115/54098
タイトル	Aspartame-induced apoptosis in PC12 cells
著者	Horio, Yukari ; Sun, Yongkun ; Liu, Chuang ; Saito, Takeshi ; Kurasaki, Masaaki
著者名 Horio, Yukari
著者名 Sun, Yongkun
著者名 Liu, Chuang
e-Rad_Researcher 40153811 著者名 Saito, Takeshi
e-Rad_Researcher 80161727 著者名 Kurasaki, Masaaki
言語	英語
キーワード	Aspartame
	Apoptosis
	Caspases
	AIF
	PC12
	Cytochrome c
発行日	2014-01
出版者	Elsevier, B.V.
収録物名	Environmental Toxicology and Pharmacology
巻(号)	37(1)
ページ	158-165
抄録	Aspartame is an artificial sweetner added to many low-calorie foods. The safety of aspartame remains controversial even though there are many studies on its risks. In this study, to understand the physiological effects of trace amounts of artificial sweetners on cells, the effects of aspartame on apoptosis were investigated using a PC12 cell system. In addition, the mechanism of apoptosis induced by aspartame in PC12 cells and effects on apoptotic factors such as cytochrome c, apoptosis-inducing factor, and caspase family proteins were studied by Western blotting and RT-PCR. Aspartame-induced apoptosis in PC12 cells in a dose-dependent manner. In addition, aspartame exposure increased the expressions of caspases 8 and 9, and cytochrome c. These results indicate that aspartame induces apoptosis mainly via mitochondrial pathway involved in apoptosis due to oxigen toxicity.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1382-6689
NCID	AA11526671
関連情報	PMID 24355796
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.etap.2013.11.021