Dose-volume analysis for respiratory toxicity in intrathoracic esophageal cancer patients treated with definitive chemoradiotherapy using extended fields

Tanabe, Satoshi; Myojin, Miyako; Shimizu, Shinichi; Fujino, Masaharu; Takahashi, Hiroaki; Shirato, Hiroki; Ito, Yoichi M.; Ishikawa, Masayori; Hosokawa, Masao

Dose-volume analysis for respiratory toxicity in intrathoracic esophageal cancer patients treated with definitive chemoradiotherapy using extended fields

Tanabe, Satoshi; Myojin, Miyako; Shimizu, Shinichi et al.

Journal of radiation research, 2013, 54(6), 1085-1094

Permalink : https://hdl.handle.net/2115/54116

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アクセス権	open access
URI	https://hdl.handle.net/2115/54116
タイトル	Dose-volume analysis for respiratory toxicity in intrathoracic esophageal cancer patients treated with definitive chemoradiotherapy using extended fields
著者	Tanabe, Satoshi ; Myojin, Miyako ; Shimizu, Shinichi ; Fujino, Masaharu ; Takahashi, Hiroaki ; Shirato, Hiroki ; Ito, Yoichi M. ; Ishikawa, Masayori ; Hosokawa, Masao
著者名 Tanabe, Satoshi
著者名 Myojin, Miyako
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
著者名 Fujino, Masaharu
著者名 Takahashi, Hiroaki
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
著者名 Ito, Yoichi M.
e-Rad_Researcher 80314772 著者名 Ishikawa, Masayori
著者名 Hosokawa, Masao
言語	英語
キーワード	radiation pneumonitis
	chemoradiation
	esophageal cancer
	dose-volume histogram
	extended-field
	dosimetric parameter
発行日	2013-11
出版者	Oxford univ press
収録物名	Journal of radiation research
巻(号)	54(6)
ページ	1085-1094
抄録	Purpose: We evaluated the relationship between dosimetric parameters (DPs) and the incidence of radiation pneumonitis (RP) and investigated the feasibility of a proposed treatment planning technique with the potential of reducing RP in esophageal cancer patients treated with definitive chemoradiotherapy using extended fields. Patients and Methods: A total of 149 patients with locally advanced esophageal cancer were prospectively enrolled for extended-field radiotherapy (EFRT) to three-field regional lymphatics between September 2004 and June 2009. We retrospectively reviewed 86 consecutive patients who were treated with a total dose of 50.4 Gy (plus an optional 9 Gy boost) and were available for dose-volume analysis. Lung DPs of patients in the Grade 0-1 RP (RPG < 1) group and the Grade 2-5 RP (RPG >= 2) group were compared. We compared the proposed plan with the conventional plan to 50.4 Gy on DPs for each case. Results: Of these 86 patients, 10 (12%) developed RPG >= 2 (Grade 2, n = 2 patients; Grade 3, n = 3; Grade 4, n = 3; Grade 5, n = 2). The patients in the RPG < 1 group showed significantly lower (P < 0.05) V5 and V10 values for the whole lung compared with those in the RPG >= 2 group. There were two advantages gained from the proposed plan for V5 (< 55%) and V10 (< 37%) values and the conformity of the PTV. Conclusion: The increase in the volume of the lung exposed to low doses of EFRT was found to be associated with the incidence of RP. Our proposed plan is likely to reduce the incidence of RP.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
権利情報	Creative Commons Attribution 3.0 Unported
PISSN	0449-3060
NCID	AA00705792
関連情報	PMID 23660276
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1093/jrr/rrt047