Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins

Noyori, Osamu; Nakayama, Eri; Maruyama, Junki et al.

Biochemical and Biophysical Research Communications, 2013, 441(4), 994-998

Permalink : https://hdl.handle.net/2115/54596

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アクセス権
open access
URI
https://hdl.handle.net/2115/54596
タイトル
Suppression of Fas-mediated apoptosis via steric shielding by filovirus glycoproteins
著者
Noyori, Osamu ; Nakayama, Eri ; Maruyama, Junki ; Yoshida, Reiko ; Takada, Ayato
著者名
Noyori, Osamu
著者名
Nakayama, Eri
著者名
Maruyama, Junki
著者名
Yoshida, Reiko
e-Rad_Researcher
10292062
著者名
Takada, Ayato
言語
英語
キーワード
Filovirus
Glycoprotein
Steric shielding
Apoptosis
Fas
発行日
2013-11-29
出版者
Elsevier
収録物名
Biochemical and Biophysical Research Communications
巻(号)
441(4)
ページ
994-998
抄録
Apoptotic death of virus-infected cells is generally thought to be a defense mechanism to limit the spread of infectious virions by eliminating virus-producing cells in host animals. On the other hand, several viruses have been shown to have anti-apoptotic mechanisms to facilitate efficient viral replication and transmission. In this study, we found that the filovirus glycoprotein (GP) expressed on cell surfaces formed a steric shield over the Fas molecule and that GP-expressing cells showed resistance to cell death induced by a Fas agonistic antibody. These results suggest that filovirus GP-mediated steric shielding may interfere with the Fas-induced apoptotic signal transduction in infected cells and serve as an immune evasion mechanism for filoviruses. (C) 2013 Elsevier Inc. All rights reserved.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
PISSN
0006-291X
関連情報
PMID
24239546
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1016/j.bbrc.2013.11.018