Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis

Nakazawa, Daigo; Tomaru, Utano; Ishizu, Akihiro

Clinical and Experimental Nephrology, 2013, 17(5), 631-633

Permalink : https://hdl.handle.net/2115/54623

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アクセス権
open access
URI
https://hdl.handle.net/2115/54623
タイトル
Possible implication of disordered neutrophil extracellular traps in the pathogenesis of MPO-ANCA-associated vasculitis
著者
Nakazawa, Daigo ; Tomaru, Utano ; Ishizu, Akihiro
著者名
Nakazawa, Daigo
e-Rad_Researcher
20360901
著者名
Tomaru, Utano
e-Rad_Researcher
60321957
著者名
Ishizu, Akihiro
言語
英語
キーワード
NETs
PTU
MPO-ANCA
MPO-AAV
発行日
2013-10
出版者
Springer
収録物名
Clinical and Experimental Nephrology
巻(号)
17(5)
ページ
631-633
抄録
Neutrophil extracellular traps (NETs) are characterized by the presence of extracellular DNA fibers studded with antimicrobial proteins, including myeloperoxidase (MPO). Although NETs play an important role in the innate immune system, the scattered extracellular enzymes, such as MPO, pose risks to the host. Therefore, NETs are strictly regulated by DNase I in the serum, which prevents them from persisting. Recent studies have demonstrated that dysregulation of NETs could be involved in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus. In this review, we interpret the association of disordered NETs with autoimmune diseases, especially propylthiouracil-induced MPO-ANCA-associated vasculitis.
資源タイプ
学術雑誌論文
出版タイプ
Accepted Manuscript
権利情報
The final publication is available at www.springerlink.com
PISSN
1342-1751
EISSN
1437-7799
関連情報
PMID
23224024
関連情報 (isVersionOf)
出版社版DOI
https://doi.org/10.1007/s10157-012-0738-8