Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer

Nishioka, Kentaro; Shimizu, Shinichi; Shinohara, Nobuo; Ito, Yoichi M.; Abe, Takashige; Maruyama, Satoru; Kinoshita, Rumiko; Harada, Keiichi; Nishikawa, Noboru; Miyamoto, Naoki; Onimaru, Rikiya; Shirato, Hiroki

Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer

Nishioka, Kentaro; Shimizu, Shinichi; Shinohara, Nobuo et al.

Japanese Journal of Clinical Oncology, 2014, 44(1), 28-35

Permalink : https://hdl.handle.net/2115/54721

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アクセス権	open access
URI	https://hdl.handle.net/2115/54721
タイトル	Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer
著者	Nishioka, Kentaro ; Shimizu, Shinichi ; Shinohara, Nobuo ; Ito, Yoichi M. ; Abe, Takashige ; Maruyama, Satoru ; Kinoshita, Rumiko ; Harada, Keiichi ; Nishikawa, Noboru ; Miyamoto, Naoki ; Onimaru, Rikiya ; Shirato, Hiroki
e-Rad_Researcher 80463743 著者名 Nishioka, Kentaro
e-Rad_Researcher 50463724 著者名 Shimizu, Shinichi
e-Rad_Researcher 90250422 著者名 Shinohara, Nobuo
e-Rad_Researcher 10334236 著者名 Ito, Yoichi M.
e-Rad_Researcher 10399842 著者名 Abe, Takashige
e-Rad_Researcher 80507591 著者名 Maruyama, Satoru
e-Rad_Researcher 70507582 著者名 Kinoshita, Rumiko
著者名 Harada, Keiichi
著者名 Nishikawa, Noboru
e-Rad_Researcher 00552879 著者名 Miyamoto, Naoki
e-Rad_Researcher 80374461 著者名 Onimaru, Rikiya
e-Rad_Researcher 20187537 著者名 Shirato, Hiroki
言語	英語
キーワード	bladder cancer
	image-guided radiation therapy
	combined modality therapy
発行日	2014-01
出版者	Oxford University Press
収録物名	Japanese Journal of Clinical Oncology
巻(号)	44(1)
ページ	28-35
抄録	Objective: The real-time tumor-tracking radiotherapy system with fiducial markers has the advantage that it can be used to verify the localization of the markers during radiation delivery in real-time.We conducted a prospective Phase II study of image-guided local-boost radiotherapy for locally advanced bladder cancer using a real-time tumor-tracking radiotherapy system for positioning, and here we report the results regarding the safety and efficacy of the technique. Methods: Twenty patients with a T2-T4N0M0 urothelial carcinoma of the bladder who were clinically inoperable or refused surgery were enrolled. Transurethral tumor resection and 40 Gy irradiation to the whole bladder was followed by the transurethral endoscopic implantation of gold markers in the bladder wall around the primary tumor. A boost of 25 Gy in 10 fractions was made to the primary tumor while maintaining the displacement from the planned position at less than +2 mm during radiation delivery using a real-time tumor-tracking radiotherapy system. The toxicity, local control and survival were evaluated. Results: Among the 20 patients, 14 were treated with concurrent chemoradiotherapy. The median follow-up period was 55.5 months. Urethral and bowel late toxicity (Grade 3) were each observed in one patient. The local-control rate, overall survival and cause-specific survival with the native bladder after 5 years were 64, 61 and 65%. Conclusions: Image-guided local-boost radiotherapy using a real-time tumor-tracking radiotherapy system can be safely accomplished, and the clinical outcome is encouraging. A larger prospective multi-institutional study is warranted for more precise evaluations of the technological efficacy and patients’ quality of life.
資源タイプ	学術雑誌論文
出版タイプ	Version of Record
PISSN	0368-2811
EISSN	1465-3621
関連情報	PMID 24302759
関連情報 (isIdenticalTo)	出版社版DOI https://doi.org/10.1093/jjco/hyt182