Essential thrombocythemia as a risk factor for stillbirth

Umazume, Takeshi; Yamada, Takahiro; Akaishi, Rina; Araki, Naoto; Nishida, Ryutaro; Morikawa, Mamoru; Minakami, Hisanori

Essential thrombocythemia as a risk factor for stillbirth

Umazume, Takeshi; Yamada, Takahiro; Akaishi, Rina et al.

Thrombosis research, 2014, 133(2), 158-161

Permalink : https://hdl.handle.net/2115/54731

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アクセス権	open access
URI	https://hdl.handle.net/2115/54731
タイトル	Essential thrombocythemia as a risk factor for stillbirth
著者	Umazume, Takeshi ; Yamada, Takahiro ; Akaishi, Rina ; Araki, Naoto ; Nishida, Ryutaro ; Morikawa, Mamoru ; Minakami, Hisanori
e-Rad_Researcher 00807935 著者名 Umazume, Takeshi
e-Rad_Researcher 20419948 著者名 Yamada, Takahiro
著者名 Akaishi, Rina
著者名 Araki, Naoto
著者名 Nishida, Ryutaro
e-Rad_Researcher 00374380 著者名 Morikawa, Mamoru
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
言語	英語
キーワード	Deep vein thrombosis
	Essential thrombocythemia
	Low-dose aspirin
	Placental abruption
	Preeclampsia
	Stillbirth
発行日	2014-02
出版者	Pergamon-elsevier science ltd
収録物名	Thrombosis research
巻(号)	133(2)
ページ	158-161
抄録	Introduction: The risk of abortion is known to be high in women with essential thrombocythemia (ET). However, a few studies have focused on the risk of stillbirth among fetuses reaching gestational age compatible with life. Methods: Review of medical charts of pregnant women with ET who received cares at a single center between January 2003 and June 2013 and the English literature in which more than 20 pregnancies with ET were dealt with regarding outcomes. Outcomes were classified into three categories: spontaneous abortion or preterm delivery before GW 24, stillbirth at and after GW 24, and live birth (LB). Japan national statistics was used to estimate the risk of stillbirth among women with GW 22 or more. Results: In all nine pregnancies in four women with ET at our hospital, two miscarriages, one stillbirth (intrauterine death at GW 35), and six LBs occurred. There were six reports in the English literature in which a total of 374 pregnancy outcomes were described: 110 miscarriages (29%), 14 stillbirths (3.7% of all 374 pregnancies and 5.3% of 264 pregnancies with GW >= 24), and 250 LBs (67%) occurred. Japan national statistics between 1995 and 2011 indicated that the risk of stillbirth was less than 0.50% among women with GW >= 22. Conclusions: The risk of still birth was extremely high among women with ET. More intensified monitoring of fetal wellbeing may be required to improve outcome of pregnancy complicated with ET. (C) 2013 Elsevier Ltd. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	0049-3848
NCID	AA00863148
関連情報	PMID 24268792
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.thromres.2013.11.004