Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

Yamada, Takashi; Koyama, Takahiro; Furuta, Itsuko; Morikawa, Mamoru; Yamada, Takahiro; Minakami, Hisanori

Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women

Yamada, Takashi; Koyama, Takahiro; Furuta, Itsuko et al.

Hypertension in Pregnancy, 2013, 32(1), 96-103

Permalink : https://hdl.handle.net/2115/54734

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アクセス権	open access
URI	https://hdl.handle.net/2115/54734
タイトル	Association of Antithrombin Activity with Plasma Aldosterone Concentration and Plasma Renin Activity in Pregnant Women
著者	Yamada, Takashi ; Koyama, Takahiro ; Furuta, Itsuko ; Morikawa, Mamoru ; Yamada, Takahiro ; Minakami, Hisanori
e-Rad_Researcher 20374283 著者名 Yamada, Takashi
著者名 Koyama, Takahiro
e-Rad_Researcher 70238682 著者名 Furuta, Itsuko
e-Rad_Researcher 00374380 著者名 Morikawa, Mamoru
e-Rad_Researcher 20419948 著者名 Yamada, Takahiro
e-Rad_Researcher 40102256 著者名 Minakami, Hisanori
言語	英語
キーワード	aldosterone
	antithrombin activity
	blood vessel permeability
	hypertension
	preeclampsia
	renin activity
発行日	2013-02
出版者	Informa Healthcare
収録物名	Hypertension in Pregnancy
巻(号)	32(1)
ページ	96-103
抄録	Objective. To test the hypothesis that the blood antithrombin (AT) activity is correlated with the plasma aldosterone concentration (PAC), the plasma renin activity (PRA), and/or the PAC-to-PRA ratio during the late stage of pregnancy. Methods. The AT activity, PAC, and PRA were determined within 7 days prior to delivery in 47 women, consisting of 30 normotensive and 6 hypertensive women with singleton pregnancies and 11 normotensive women with twin pregnancies. Results. The median values of the 47 women were 86% of the normal activity level for the AT activity, 442 pg/mL for the PAC, 3.7 ng/mL/h for the PRA, and 108 pg/mL per ng/mL/h for the PAC-to-PRA ratio. Women with an AT activity ≤86% had a significantly lower PRA and a higher PAC-to-PRA ratio than women with an AT activity >86% (3.5 ± 3.0 vs. 6.6 ± 4.7 ng/mL/h for PRA, p = 0.008; 156 ± 109 vs. 97 ± 46 pg/mL per ng/h for PAC-to-PRA ratio, p = 0.021). The AT activity was significantly correlated positively with the PRA and negatively with the PAC-to-PRA ratio. Conclusions. The existence of a common pathophysiological background between a reduced AT activity and a reduced PRA during the late stage of pregnancy was suggested.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1064-1955
EISSN	1525-6065
NCID	AA10910120
関連情報	PMID 23273069
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.3109/10641955.2012.751995