Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier

Yamada, Yuma; Harashima, Hideyoshi

Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier

Yamada, Yuma; Harashima, Hideyoshi

Mitochondrion, 2013, 13(5), 526-532

Permalink : https://hdl.handle.net/2115/54782

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アクセス権	open access
URI	https://hdl.handle.net/2115/54782
タイトル	Enhancement in selective mitochondrial association by direct modification of a mitochondrial targeting signal peptide on a liposomal based nanocarrier
著者	e-Rad_Researcher 60451431 著者名 Yamada, Yuma
著者	e-Rad_Researcher 00183567 著者名 Harashima, Hideyoshi
言語	英語
キーワード	Mitochondria
	Mitochondrial drug delivery
	Mitochondrial targeting signal peptide (MTS)
	MITO-Porter
	Membrane fusion
	Nanotechnology
発行日	2013-09
出版者	Elsevier sci ltd
収録物名	Mitochondrion
巻(号)	13(5)
ページ	526-532
抄録	The focus of this study was on the development of a nano carrier targeted to mitochondria, a promising therapeutic drug target. We synthesized a lipid derivative that is conjugated with a mitochondrial targeting signal peptide (MTS), which permits the selective delivery of certain types of proteins to mitochondria. We then explored the use of an innovative technology in which MTS and the MITO-Porter were integrated. The latter is a liposome that delivers cargos to mitochondria via membrane fusion. The results indicate that the combination of MTS and the MITO-Porter would be useful for selective mitochondrial delivery via membrane fusion. (C) 2012 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
資源タイプ	学術雑誌論文
出版タイプ	Accepted Manuscript
PISSN	1567-7249
関連情報	PMID 23000575
関連情報 (isVersionOf)	出版社版DOI https://doi.org/10.1016/j.mito.2012.09.001